- Docente: Andrea Sapone
- Credits: 3
- SSD: BIO/14
- Language: Italian
- Teaching Mode: In-person learning (entirely or partially)
- Campus: Bologna
- Corso: First cycle degree programme (L) in Environment and Workplace Prevention Techniques (cod. 8487)
Learning outcomes
Pharmacokinetics and pharmacodynamics.
Course contents
Pharmacology (Prof. Tonelli)
General definition of Pharmacology, pharmacotherapy and their scopes. Concepts of Drug, medicament, poison.
Pharmacodinamics: sites and mechanisms of drug actions; Classifications of the receptors, time dependent dose/effect relations; agonist, partial agonist and antagonist drugs; factors that modify the activity of the drugs; collateral effects induced by iperdose, idiosyncrasy and allergy; teratogenesis. Pharmacological and therapeutic effects.
Pharmacokinetics: general principles of the passage of the drugs through the biological membranes the blood brain barrier and the plancental barrier; routes of drug administration and absorbtion. Drug binding to the plasma proteins; Drug distribution; Drug biotransformation; drug elimination; bioavailability; drug half-life.
Evaluation of the pharmacokinetic parameters. Variability in the drug response: drug-dependent factors and pharmaceutical formulation-dependent factors; factors dependent from the person (genetic factors, dietetic factors, body weight, age, sex,
pregnancy, pathological states stati patologici, complications); factors related to the environment; factors related to the exposition conditions (tollerance; tachyphylaxis; physical and psychical dependence). Drug interactions.
Adverse effects of the drugs: dose-dependent effects, predictable and avoidable effects; predictable and unavoidable effects; dose-independent and unpredictable effects.
Abnormal responses to the drug administration: idiosyndratic reactions, allergic reactions.
Pharmacology of the nervous system, cardiovascular pharmacology, respiratory Pharmacology, Digestive pharmacology, inflammation pharmacology.
Toxicology (Prof. Sapone)
Toxicokinetics and toxicodynamics.
Readings/Bibliography
Contact directly Dr. Sapone.
Teaching methods
Lectures in Italian.
Assessment methods
Contact directly Dott. Sapone or Tonelli.
Teaching tools
Lectures in Italian.
Office hours
See the website of Andrea Sapone