Abstract
The InBLOOM project investigates the role of the blood microbiome in colorectal cancer (CRC) etiology and detection. Based on a case-control study including 100 CRC patients, 100 with intestinal adenomas and 100 healthy controls, the project builds on preliminary 16S rRNA analyses and detailed lifestyle and dietary data. Using shotgun metagenomics, InBLOOM will characterize the taxonomy, function, and origin of circulating microbial DNA in blood. Multivariate models will link blood microbiome features to CRC risk, identify potential diagnostic biomarkers, and assess associations with lifestyle factors. This innovative approach aims to clarify the microbial contribution to the adenoma–carcinoma sequence and improve CRC prevention strategies.
Project details
Unibo Team Leader: Simone Rampelli
Unibo involved Department/s:
Dipartimento di Farmacia e Biotecnologie
Coordinator:
ALMA MATER STUDIORUM - Università di Bologna(Italy)
Total Eu Contribution: Euro (EUR) 229.208,00
Total Unibo Contribution: Euro (EUR) 129.314,00
Project Duration in months: 24
Start Date:
30/11/2023
End Date:
28/02/2026
