Abstract
Infections and inflammation of the female genital tract highly impact women’s quality of life. Aerobic and enteric bacteria generally behave as vaginal commensals but, in certain conditions, can lead to aerobic vaginitis; Lactobacillus spp. exert antagonistic activity towards genital pathogens, but their contribution to vaginal health is still fragmented, also because of the lack of appropriate models. CrispOmics aims to dissect the crosstalk between the vaginal epithelium, the beneficial members of the resident microbiota and pathogens. Optimized interaction models host-microbiota-pathogen will be developed and analyzed by an “omics” approach. Data obtained by transcriptomics, untargeted proteomics and metabolomics will be integrated to identify the major driving forces of the pathogenic switching, providing deeper understanding of bacterial infections insurgence. CrispOmics will prompt the elaboration of preventive strategies based on the endogenous defenses to improve women’s health.
Project details
Unibo Team Leader: Carola Eleonora Parolin
Unibo involved Department/s:
Dipartimento di Farmacia e Biotecnologie
Coordinator:
ALMA MATER STUDIORUM - Università di Bologna(Italy)
Total Eu Contribution: Euro (EUR) 236.947,00
Total Unibo Contribution: Euro (EUR) 118.474,00
Project Duration in months: 24
Start Date:
30/11/2023
End Date:
28/02/2026
