Abstract
The key importance of the cellular innate immunity both in controlling invasive infection has been known for decades, but there is a dramatic lack of functional information on the events which take place in tissue macrophages within the human spleen upon microbial infection. To explore early events in the human spleen, in the present project we will dissect interactions of tissue macrophages. To this aim, we will infect human spleens, during ex vivo organ perfusion, with Klebsiella pneumoniae. Serial biopsy samples will be analysed and commercially available molecules targeting markers identified, will then be tested. We envisage that this research proposal will be able to deliver novel insight into the management of invasive infection and lead to developments in host directed antimicrobial treatment. This work is envisaged to generate a set of general rules for a more efficient clinical management of systemic infectious agents in general.
Project details
Unibo Team Leader: Marco Rinaldo Oggioni
Unibo involved Department/s:
Dipartimento di Farmacia e Biotecnologie
Coordinator:
ALMA MATER STUDIORUM - Università di Bologna(Italy)
Total Eu Contribution: Euro (EUR) 239.297,00
Total Unibo Contribution: Euro (EUR) 135.552,00
Project Duration in months: 24
Start Date:
30/11/2023
End Date:
28/02/2026
