Abstract
Alzheimer's disease (AD), the most common form of dementia, is marked by amyloid plaque (Aβ) accumulation, tau hyperphosphorylation, neuroinflammation, and neuronal degeneration. Despite significant efforts, effective treatment remains lacking. Disrupted communication between neurons and glia plays a key role in AD onset, with microglia-mediated neuroinflammation exacerbating neuronal damage. Extracellular vesicles (EVs) are involved in spreading neuroinflammation and toxic protein aggregates. EVs from neural stem cells (NSC-EVs) show promise in modulating neuroinflammation and enhancing neurogenesis in AD models. This study aims to examine adult neurogenesis and EV characteristics in the 5XFAD model, focusing on miRNA profiles and their potential as therapeutic targets for AD, which may lead to innovative treatments.
Project details
Unibo Team Leader: Francesca Massenzio
Unibo involved Department/s:
Dipartimento di Farmacia e Biotecnologie
Coordinator:
Università degli studi di Modena e Reggio Emilia - UNIMORE(Italy)
Total Unibo Contribution: Euro (EUR) 93.894,00
Project Duration in months: 24
Start Date:
18/10/2023
End Date:
28/02/2026
