The main driving idea of the project is the creation of conceptually new type of scaffolds able to be manipulated in situ by means of magnetic forces. This approach is expected to generate scaffolds with such characteristics as multiple use and possibly multipurpose delivery in order to repair large bone defects and ostheocondral lesions in the articular surface of the skeletal system. The provision in vivo of the scaffold with staminal cells or /and growth factors in order to drive the tissue differentiation process and parallel angiogenesis represents nowadays one of most challenging requests. The Consortium aims to elaborate, investigate and fabricate new kind of scaffolds – magnetic scaffolds (MagS) - characterized by strongly enhanced control and efficiency of the tissue regeneration and angiogenic processes. Such a magnetic scaffold can be imagined as a fixed "station" that offers a long-living assistance to the tissue engineering, providing thus a unique possibility to adjust the scaffold activity to the personal needs of the patient.
Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE (Italy)
Other participants
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
- Dip. di Scienze Anatomiche Umane e Fisiopatologia dell'Apparato Locomotore
- Resp. scientifico: Prof. Maurilio Marcacci
FIN-CERAMICA FAENZA S.p.A. (Italy)
RUPRECHT-KARLSUNIVERSITAET HEIDELBERG (Germany)
UNIVERSIDAD POLITECNICA DE VALENCIA (Spain)
BIO-VAC España, S.A. (Spain)
Universidade de Santiago de Compostela (Spain)
FORSCHUNGSZENTRUM ROSSENDORF EV (Germany)
EIDGENOESSISCHE MATERIALPRUEFUNGS- UND
FORSCHUNGSANSTALT (Switzerland)
THE UNIVERSITY OF EDINBURGH (UK)
SVEUCILISTE U ZAGREBU, MEDICINSKI FAKULTET (Croatia)
UNIVERSITAETSSPITAL BASEL (Switzerland)
INVENT SAS (France)
I+ SRL (Italy)
BIODEVICE SYSTEMS SRO (Czech Republic)
Belarussian State Medical University (Belarus)
Explora S.r.l. (Italy)
AvantiCell Science Ltd (UK)
Central Institute of Orthopedics and Traumatology of Russia (Russia)
University of Brighton (UK)
Start date 01/12/2008
End date 30/11/2012
Duration 48 months
Project cost 11.085.124 Euro
Project Funding 8.278.091 Euro
Subprogramme Areas Highly porous bioactive scaffolds favouring angiogenesis for tissue engineering
Contract type Large Scale Integrating Project