- Docente: Riccardo Amorati
- Credits: 4
- SSD: CHIM/06
- Language: English
- Teaching Mode: Traditional lectures
- Campus: Rimini
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Corso:
Single cycle degree programme (LMCU) in
Pharmacy (cod. 5987)
Also valid for Single cycle degree programme (LMCU) in Pharmacy (cod. 9078)
Learning outcomes
At the end of the course students will be familiar with the radical reactions involved in the oxidation of organic materials and on the main mechanisms for antioxidant protection. The student will know the main classes of natural and synthetic antioxidants and the structure-activity relationships for antioxidant behavior. He/She will have developed a critical attitude in the evaluation of a potential antioxidant. The student will know the main methods to test the antioxidant activity in model systems, either chemical or biomimetic.
Course contents
1) Structure and properties of free radicals. Stability of radicals, BDE. Main radical reactions and radical species involved.
2) Reaction of auto-oxidation. Initiation (photochemistry, thermal, redox), propagation (HAT, addition), termination. Non-radical reactions of hydroperoxides. Oxidation of biological molecules and drugs.
3) Antioxidants. General characteristics and mechanisms of action (preventive and chain-breaking). Phenols as antioxidants, phenoxy radicals. BDE of the phenolic bond. Kinetic aspects of autoxidation inhibited by phenols. Constant of inhibition. Catalytic antioxidants (aromatic amines, nitroxides). Natural and synthetic antioxidants.
4) Measure the antioxidant activity. Methods based on inhibited autoxidation: measurement of O2 consumption, peroxide formation, conjugated dienes, consumption of oxidizable probes. Approximate methods: ORAC, DPPH, ABTS.
5) Oxidative stress in biological systems. Natural antioxidant defenses. Ferroptosis.Readings/Bibliography
Lecture notes and material uploaded to Virtuale
Teaching methods
The lectures will involve the use power-point presentations. Problem solving sessions will be carried out for the student to gain acquaintance with the numeric treatment of chemical problems.
Assessment methods
Verification of learning takes place through the preparation of a power point presentation (about 15 slides long) in which a scientific article on the topics covered in class is discussed.
The grade will depend on:
1) comprehension of the specific topic;
2) inclusion in the presentation of some concepts explained during the course;
3) active participation to the presentation of other students by asking interesting questions.
In order to take the examination, the student must have attended at least 80% of the laboratory exercises and 70% of the lectures. Students are reminded to check the prerequisites listed in the course structure diagram.
Students with learning disorders and\or temporary or permanent disabilities: please, contact the office responsible (https://site.unibo.it/studenti-con-disabilita-e-dsa/en/for-students) as soon as possible so that they can propose acceptable adjustments. The request for adaptation must be submitted in advance (15 days before the exam date) to the lecturer, who will assess the appropriateness of the adjustments, taking into account the teaching objectives.
Teaching tools
Multimedia material will be presented, such as slides, movies, animations and three-dimensional visualization of atoms, molecules and materials.
The multimedial material utilized during the lectures will be made available for download from the teacher's web site.
Students are asked to report any needs to the teacher via private mail. This will allow the teacher to evaluate which teaching support tools are most adequate to make the course accessible to all students.Office hours
See the website of Riccardo Amorati