57176 - Applied Clinical Pathology

Learning outcomes

At the end of the course students will have acquired the fundamental knowledge to critically evaluate and interpret the results of the more used diagnostic approaches in hepatic, cardiovascular and haemostasis pathologies.

Course contents

Part 1

1) Laboratory testing for the diagnostics of cardiovascular diseases

2) Laboratory testing in the assessment of atherosclerosis risk factors

3) Laboratory testing in evaluating the biocompatibility of implant materials

Part 2

1) Diagnostic approaches for personalized treatments: "precision medicine"

2) Tumor markers and cancer diagnostics: traditional and innovative approaches

3) Diagnostic applications of DNA amplification. Principles and diagnostic use of the following techniques:

a) real time PCR,

b) digital PCR,

c) loop mediated isothermal amplification (LAMP).

Readings/Bibliography

- Marcello Ciaccio e Giuseppe Lippi: Biochimica Clinica e Medicina di Laboratorio. Terza edizione, 2020 EdiSES Università S.r.l. - Napoli

- Michael Laposata: Medicina di Laboratorio: la diagnosi di malattia nel laboratorio clinico. 2012, Piccin Nuova Libraria S.p.A. Padova.

- Italo Antonozzi e Elio Gulletta: Medicina di Laboratorio: Logica & Patologia Clinica. 2013, Piccin Nuova Libraria S.p.A. Padova

Teaching methods

Lectures and illustrations of laboratory applications

Assessment methods

Written Exam.

The exam will consist of open questions on the topics covered during the lectures. The test must be completed in 45 minutes.

All modules of the integrated course will contribute to the overall assessment and the final grade will correspond to the weighted average (based on CFU credits) of the marks obtained for each module of the Integrated Course. Cum laude may be awarded, upon proposal by at least one professor, only if the student has obtained the maximum grade (30/30) in all the modules included in the exam.

In the written exam, the student will answer questions on topics explained by the professor. The questions are designed to assess the depth of study, the ability to critically connect different areas of knowledge, and the achievement of an integrated understanding of the topics discussed during the lectures.

Final grade scale. Fail: inadequate preparation; serious and repeated conceptual errors. 18–19: basic understanding without major gaps; overall correct language. 20–24: solid knowledge of basic concepts with no significant gaps; correct language use. 25–29: good or very good preparation, or excellent preparation with minor inaccuracies in the exposition that prevent the award of the highest grade; good command of subject-specific terminology. 30–30L: comprehensive, consolidated preparation with no inaccuracies in the topics covered; optimal use of technical terminology and strong argumentative skills.

Students with learning disorders or with temporary or permanent disabilities are encouraged to contact the dedicated office (https://site.unibo.it/studenti-con-disabilita-e-dsa/it/per-studenti ) as early as possible to define appropriate compensatory measures. The request must be submitted to the professor at least 15 days before the exam date, so that its coherence with the learning objectives can be assessed.

The final mark of the integrated course Clinical Pathology II will be the average of the marks obtained in the exams of Applied Clinical Pathology, Genetic Clinical Pathology and Techniques of Clinical Pathology 2.

Teaching tools

Slides used in support of teaching will be available online on virtuale.unibo.it website.

Office hours

See the website of Carla Renata Arciola

See the website of Lorenzo Montanaro