73819 - Analytical-Toxicological Approach to Drugs of Abuse

Academic Year 2016/2017

  • Docente: Maria Augusta Raggi
  • Credits: 3
  • SSD: CHIM/08
  • Language: Italian
  • Teaching Mode: In-person learning (entirely or partially)
  • Campus: Bologna
  • Corso: First cycle degree programme (L) in Applied Pharmaceutical Sciences (cod. 8518)

    Also valid for First cycle degree programme (L) in Applied Pharmaceutical Sciences (cod. 8518)

Learning outcomes

At the end of the course the student should have knowledge of the chemical structures of the main classes of drugs of abuse, their toxicological properties with particular regard to the class of alkaloids. The student will be able to select suitable test for the identification and quantitation of drugs of abuse .

Course contents

The teaching programme consists of 3CFU of lectures.

The chemical structures and toxicological properties of main drugs will be described.
The course program will cover analytical techniques for the identification and quantitative analysis of major classes of drugs of abuse: cannabinoids, opioids, cocaine, amphetamines, "club drugs", "smart drugs", NSP.

It will also consider the techniques of sampling, transport and storage of samples from the different matrices.

Moreover, the procedures necessary for development and validation of analytical methods for the abuse substances  and metabolites monitoring will be described.

Readings/Bibliography

Only as a reference:

- H. Brandenberger, R.A.A. Maes "Analytical toxicology for clinical, forensic and pharmaceutical chemists". deGruyter, 1997.

- K.A. Rubinson, J.F. Rubinson "Chimica Analitica Strumentale". Zanichelli, 2002.

- Clarkes analysis of drugs and poisons: in pharmaceuticals , body fluids and postmortem materials. 1.-3. Ed. - London; Chicago: PhP Pharmaceutical Press, 2004-XXI,564.

 

Assessment methods

The student's learning will be verified in progress during lessons with questions about the explained topics. In particular the skills will be assessed in relation to:
-major classes of drugs of abuse (cannabinoids, opiates, amphetamines, alkaloids, smart drugs and club drugs)

- knowledge of the chemical structures and toxicity of the examined compounds

-qualitative and quantitative analysis of drugs of abuse and their metabolites

Final assessment will be carried out with 3 questions on the topics discussed during the lessons.

Teaching tools

Slides of the lectures and scientific papers.

Office hours

See the website of Maria Augusta Raggi