35802 - Pathology of Laboratory Animals and Animal Models of Human Diseases

Learning outcomes

Acquisition of knowledge on gross and microscopic features of conditions which may affect laboratory animals, as for specific lesions in organ systems, and their pathogenesis.  Acquisition of knowledge on morphophisiopathology of animal models of human disease, particularly of immunological and vascular diseases and shock. Ability to properly recognize and describe a lesion with appropriate terminology, and to evaluate similarities and differences among interpecies models of diseases.

Course contents

PATHOLOGY OF LABORATORY ANIMALS (3 CREDITS - BETTINI)

Recognize and interpret conditions which may affect experimental results or alter the health of laboratory animals.  

The major objective of this course is to review the pathology and, where appropriate, the etiology, pathogenesis, diagnosis and control of infectious, parasitic, neoplastic, iatrogenic, nutritional, and metabolic diseases of laboratory animals.

Necropsy Techniques of laboratory animals. Sampling and processing techniques for histopathology. Pathology of respiratory, digestive, hemolymphatic, urinary, genital, nervous, muscoskeletal and cutaneous system of laboratory animals.

 

ANIMAL MODELS OF HUMAN DISEASES (2 CREDITS - SARLI)

Acquisition of knowledge on the pathogenesis of human and animal models of disease.

Acquisition of knowledge on the pathogenesis of human and animal models of disease due to immunopathologic or circulation deficit mechanisms. Animal and human models of disease caused by hypersensivity (types I, II, III, IV); immunodeficiency, autoimmune diseases, graft rejection. Animal and human models of shock, oedema, haemorragic diseases, thrombosis, ischemia, embolism.

Readings/Bibliography

• Fox JG, Cohen BJ, Loew FM. Laboratory animal medicine. Academic Press, 1984, Orlando
• Foster HL, Small JD, Fox JG. The mouse in biomedical research. Volume II. Diseases. Academic Press, 1982, Orlando
• Cheville N. F., Patologia generale veterinaria. Edizione italiana a cura di E. Cornaglia e F. Valenza, 2003 (UTET, Torino).
• Marcato P.S., Anatomia e istologia patologica generale veterinaria, 1997 (Esculapio, Bologna).
• Pontieri G.M., Patologia Generale, II edizione, 1996 (Piccin, Padova).
• Slauson D.O., Cooper B.J., Mechanisms of disease, 2002 (Mosby, Inc., Missouri, USA).
• Tizard I., Veterinary Immunology, sixth ed., 2000 (W.B. Saunders)
• Robbins e Cotran Le basi patologiche delle malattie. Kumar V, Abbas AK, Fausto N. 7° ed, elsevier, 2006.
• Files available at Alm@ DL

Teaching methods

Room lectures and seminars

Necropsy and histopathology practices on laboratory animals

Assessment methods

oral examination

Teaching tools

Videoprojector and PC for room lectures

necropsy room and microscopes for practices

Office hours

See the website of Giuliano Bettini

See the website of Giuseppe Sarli