- Docente: Isabella Orienti
- Credits: 11
- SSD: CHIM/09
- Language: Italian
- Teaching Mode: In-person learning (entirely or partially)
- Campus: Rimini
- Corso: Long cycle 2nd degree programme in Pharmacy (cod. 0040)
Learning outcomes
The course is aimed at deepen the formulative and preparative aspects of conventional and innovative drug delivery systems to find out the main correlations with their biopharmaceutical and pharmacokinetics behaviour. In particular the course point out the correlations between the physico-chemical characteristics of the excipients and the functionality of the therapeutic system.
Course contents
Bioavailability and bioequivalence.
Pharmaceutical dosage forms and pharmaceutical systems. Factors influencing drug absorption and drug availability. Pharmacokinetics. Plasma concentration time curves. Absolute bioavailability. Relative bioavailability. Bioequivalence. Dose size and frequency of administration.
Physico-chemical processes that control drug release and drug absorption.
Ficks First and Second Lows. Passive diffusion through a membrane. Partition coefficient. Dissolution. Solubility. Thermodynamic parameters. Enhanced solubility. Micellisation. Salification. Complexation.
Conventional drug delivery systems. Formulative and preparative aspects correlable with the administration route and the release characteristics. Powders, Granules, Tablets, Capsules, Solutions, Suspensions, Emulsions, Ointments, Hydrogels, Lipogels, Pastes.
Controlled drug delivery systems. Physico-chemical properties of the excipients correlable with the release characteristics.
Diffusion controlled devices. Monolithic devices. Reservoir devices. Solvent controlled devices. Osmotically controlled devices. Swelling controlled devices. Chemically controlled devices.
Drug targeting.
Passive targeting. Active targeting. Preparation of drug containing microparticulates. Liposomes. Microspheres. Microcapsules. Cells. In vivo barriers to microparticulate distribution. Macromolecular systems. Selected examples of drug delivery with microparticulate and macromolecular systems.
Readings/Bibliography
1) SWARBRICK, BOYLAN, Encyclopedia of Pharmaceutical Technology, Dekker, 1999-2005.
Teaching methods
Lessons, Laboratory exercises
Assessment methods
Oral or written examination
Teaching tools
Slides, Laboratory
Office hours
See the website of Isabella Orienti