Shedding new light on the Possible mechAnisms underlying broiler CHickens abnormalities: Gallus gallus as animal model for colLagen type 4-related muscle disorders (PACHOL4)

PRIN 2022 Soglia

Abstract

In the past decade, a group of growth-related abnormalities affecting the Pectoralis major muscles of fast-growing broiler chickens selected for meat production purposes has abruptly emerged all over the World with impressive incidence levels and severity. These spontaneous defects, known as White Striping (WS) and Wooden Breast (WB) often coexist, manifest with distinctive phenotypes, and exhibit peculiar histological features which resemble those associated to myopathic conditions in humans. This proposal, built on a recently formulated hypothesis, aims at evaluating whether an intracellular accumulation and/or an altered extracellular arrangement of COL4 may represent the primary cause underlying the occurrence of growth-related defects.

Project details

Unibo Team Leader: Francesca Soglia

Unibo involved Department/s:
Dipartimento di Scienze e Tecnologie Agro-Alimentari

Coordinator:
ALMA MATER STUDIORUM - Università di Bologna(Italy)

Total Eu Contribution: Euro (EUR) 206.752,00
Total Unibo Contribution: Euro (EUR) 133.160,00
Project Duration in months: 24
Start Date: 12/10/2023
End Date: 31/01/2026

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