Abstract
The NSO_MAP project investigates the pharmaco-toxicological and forensic risks of Nitazenes, a potent class of New Synthetic Opioids (NSO) emerging on illicit markets. Combining in vivo (mouse and zebrafish larvae) and in vitro (human cells) studies with advanced analytical techniques, the project characterizes their toxic effects, metabolism, genotoxicity, and identifies key biomarkers. Nitazene exposure will be evaluated across neurological, cardiovascular, and gender-specific responses. Mass spectrometry (LC-HRMS) will support metabolite identification in biological fluids and tissues, flow cytometry will support genotoxicity evaluation. The outcomes will aid forensic toxicology, emergency response, and legislative control, improving national and European strategies against NSO spread. Results will be shared with public agencies and scientific communities to enhance monitoring and prevention.
Project details
Unibo Team Leader: Monia Lenzi
Unibo involved Department/s:
Dipartimento di Farmacia e Biotecnologie
Coordinator:
Università degli Studi di Ferrara - Amministrazione Centrale(Italy)
Total Unibo Contribution: Euro (EUR) 99.043,00
Project Duration in months: 24
Start Date:
16/10/2023
End Date:
28/02/2026
