Course Unit Page
-
Teacher Maurizio Brigotti
-
Learning modules Maurizio Brigotti (Modulo 1)
Paolo Garagnani (Modulo 2)
-
Credits 4
-
SSD MED/04
-
Teaching Mode Traditional lectures (Modulo 1)
Traditional lectures (Modulo 2)
-
Language English
-
Campus of Bologna
-
Degree Programme Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 9210)
-
Course Timetable from Oct 27, 2022 to Jan 17, 2023
Course Timetable from Oct 18, 2022 to Jan 13, 2023
SDGs
This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.

Academic Year 2022/2023
Learning outcomes
Describe general physiopathologic processes associated with disease, including hemostasis and hemorrhage, atherosclerosis, thrombosis, embolism, infarction, hypoxia and cyanosis, and oedema.
Course contents
A- General Pathology
1- Course outline; cell adaptation (hypertrophy, atrophy, hyperplasia, metaplasia)
2- Cell injury; cellular senescence; Free radicals
3- Ca2+ related disorders; Autophagy
4- Cell death (apoptosis, necrosis, necroptosis, anoikis, pyroptosis, NETosis, entosis, ferroptosis)
5- Acute inflammation: cellular mediators
6- Acute inflammation: soluble mediators
7- Dystrophic and metastatic calcifications
8- Resolution of inflammation
9- Injuries by exotoxins and biological effects of endotoxins
10- Alcohol-related diseases
11- Chronic inflammation; granulomatous diseases
12- Steatosis
13- Wound Healing: regeneration, repair and granulation tissue; Pathogenesis of fibrosis
14- Environmental pathology (electricity, chemicals)
15- Radiation; smoking
16- Non-coding RNA related diseases
B- General Physiopathology
1-Cirrhosis and amyloidosis
2- Hypertension
3- Edema: etiology and pathogenesis
4- Atherosclerosis: etiology and pathogenesis
5- Atherosclerosis: general features and classification
6- Hypoxia and cyanosis: etiology and pathogenesis
7- Thermal regulatory dysfunction; burns; altitude-related illness
8- Systemic effects of inflammation; fever
9- Endothelial dysfunctions
10- Physiopathology of coagulation and hemorrhagic diseases
11- Thrombosis: classification, etiology and pathogenesis
12- Diabetes
13- Metagenomics and diseases
14- Embolism: classification, etiology and pathogenesis
15- Sepsis; disseminated intravascular coagulation
16-Infarction: etiology and pathogenesis; Shock: etiology and pathogenesis
Readings/Bibliography
Rubin’s Pathology 7th, Wolters Kluwer ed
Robbins and Cotran, Pathologic Basis of Disease 10th edition, Elsevier ed
Teaching methods
The General Pathology and General Physiopathology courses consist of 8 CFU of 64 hours of lectures supported by slides. Attendance to learning activities is mandatory; the minimum attendance requirement to be admitted to the final exam is 60% of lessons.
Assessment methods
Student learning will be checked at the end of the Integrated Course “Basic Mechanisms of Diseases” by an oral exam. A passing grade (i.e. mark above or equal to 18/30) in each module of the Course (Immunology, General Pathology, General Physiopathology and Gen. Path. Lab) is required to obtain the final assessment. The final mark will be calculated as the weighted mean (based on CFUs) of the four marks. Exams will be held in presence according to the indications provided by University of Bologna.
In the event of changes due to the Covid-19 pandemic, the exams could be held at distance with Microsoft Teams platform. Students should register as usual in Almaesami, and will receive an e-mail with the link and timetable of the exam sessions.
Teaching tools
Teaching slides will be available on line at Unibo e-learning website https://iol.unibo.it
Office hours
See the website of Maurizio Brigotti
See the website of Paolo Garagnani