Course Unit Page
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Teacher Valerio Cozzani
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Learning modules Valerio Cozzani (Modulo 1)
Alessandro Paglianti (Modulo 2)
Ernesto Salzano (Modulo 3)
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Credits 6
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SSD ING-IND/27
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Teaching Mode Traditional lectures (Modulo 1)
Traditional lectures (Modulo 2)
Traditional lectures (Modulo 3)
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Language English
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Campus of Bologna
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Degree Programme Second cycle degree programme (LM) in Chemical and Process Engineering (cod. 8896)
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Course Timetable from Feb 24, 2022 to Mar 25, 2022
Course Timetable from Mar 31, 2022 to May 06, 2022
Course Timetable from May 12, 2022 to May 26, 2022
SDGs
This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.
Academic Year 2021/2022
Learning outcomes
The course aims at introducing the design of unit operations and equipment specific of the pharmaceutical industry. Criteria and procedures for process design, quality control and certification will be introduced.
Course contents
Requirements/Prior knowledge
A prior knowledge and understanding of local and integral balances of mass and energy, fluid dynamics models (perfect mixing and plug flow) is required to attend with profit this course.
In addition, students should master the utilization of spreadsheets.
Fluent spoken and written English is a necessary pre-requisite, because all lectures and tutorials, and all study material will be in English.
Program
Illustration of objectives and aims of the course.
Characteristics and peculiarities of the pharmaceutical industry. Outline of pharmaceutical legislation. The quality of the product.
The concept of Active Pharmaceutical Ingredient (API) and the importance of the unit operations in the production process.
Kinetics of the chemical reactions for the synthesis of API.
Viable methods for the kinetic analysis in the synthesis of API in batch and continuous reactors.
Purification of the product: distillation and extraction.
Filtration and drying.
Kinetics of thermal destruction of microrganisms and the sterilization process.
Batch and continuous reactors. Multiphase reactors with mixing.
Case studies.
Readings/Bibliography
Chemical Engineering in the Pharmaceutical Industry: Active Pharmaceutical Ingredients, Second Edition, D.J. am Ende and M.T. am Ende (Eds.), 2019 John Wiley & Sons, Inc.
Teaching methods
Power point lecture presentations, demonstrations and practical classes.
Lectures by industry experts.
Assessment methods
The student sits an oral exam, which consists of 3-4 questions, aiming to demonstrate both the theoretical preparation and the capability of the student of solving design and analysis problems. A presentation and a critical discussion of the outcomes of the case-study will also be required.
Higher grades will be awarded to students who demonstrate a sound theoretical preparation, an organic understanding of the subject, a high ability for the practical applications, and a clear, comprehensive and concise presentation of the contents.
To obtain a passing grade, students are required to at least demonstrate a knowledge of the key concepts of the subject, some ability for critical discussion, and a comprehensible use of technical Language.
A failing grade will be awarded if the student shows knowledge gaps in key-concepts of the subject, inappropriate use of language, and/or logic failures in the analysis of the subject.
Teaching tools
Teaching material including PowerPoint slides, lecture notes are available to the students via the IOL (Insegnamenti OnLine) Platform.
Included: Analysis of case studies, Examples with the illustration of the solutions.
Office hours
See the website of Valerio Cozzani
See the website of Alessandro Paglianti
See the website of Ernesto Salzano
Alumni