20729 - Clinical Biochemistry and Clinical Molecular Biology

Course Unit Page

Academic Year 2019/2020

Learning outcomes

Describe the clinical biochemistry skills and techniques to evaluate the functional state of organs and tissues, using liquid and solid samples from patients.

Course contents

  • Course introduction
  • Clinical biochemistry
  • Biomarkers
  • Laboratory medicine: the pre-analytical, analytical and post-analytical phases
  • Variability and standardization of laboratory testing
  • Performance of a laboratory test: sensibility, specificity, predicting values and ROC curves
  • Principle of epigenetics
  • The use of genetic and epigenetic biomarkers in oncology and neurological disorders
  • The assessment of diagnostic and prognostic tests with examples from new assays based on Next Generation Sequencing for head and neck carcinomas
  • Personalized medicine: liquid biopsy to monitor the evolution of the cancer genome through a minimally invasive technique
  • Bioinformatic tools for Next Generation Sequencing analysis
  • Cerebrospinal fluid analysis in the central nervous system diseases


Files will be provided by IOL platform (.pdf slides, video, reference papers)

Teaching methods


Assessment methods

Oral examination

Teaching tools

Power point presentations, video, assessment tests using .quizizz platform

Office hours

See the website of Luca Morandi