75223 - TOXICOLOGY GENERAL

Course Unit Page

Academic Year 2018/2019

Learning outcomes

At the end of the course the student knows: - the general principles of Toxicology; - the principles governing entry, fate and effects of toxicants on living systems; -a the major genetic and environmental determinants of risk; - how to recognize, identify, and quantify the hazard resulting from exposure to chemicals; -the public health aspects of chemicals in air, water, other parts of the environment, in food and drugs. The course is concerned with general principles of risk assessment and the definition of limits of safety of chemical agents.

Course contents

General Toxicology - Origin and scope of Toxicology, classification of toxic agents, spectrum of undesired effects, dose response. Absorption, distribution, and excretion of toxicants, metabolism of toxic substances; factors that affect the rates of metabolism of foreign compounds. Factors influencing the toxicity.

Molecular and cellular aspects of Toxicology (definition, mechanisms of actions, toxic agents):Oxidative stress. Cell death. Genetic toxicology. Chemical carcinogenesis. Developmental toxicology. Teratogens.

Systemic Toxicology (mechanisms of action, toxic agents): Toxic response of the liver. Toxic response of the kidney. Toxic response of the respiratory system. Toxic response of the nervous system. Toxic response of the reproductive system. Toxic response of the immune system. Toxic response of the skin.

Toxic agents - Pesticides. Metals. Solvents and vapors. Radiations. Persistant organic pollutants. Natural toxins. Food contaminants

Readings/Bibliography

Casarett & Doull -Elementi di Tossicologia ( Hrelia P e Cantelli Forti G editors), Casa Editrice Ambrosiana, Milano, 2013

C.L. Galli, E. Corsini, M. Marinovich - Tossicologia - Piccin, Padova, 2004.

The file of the lessons are available at AMS Campus -AlmaDL - University of Bologna : http://campus.unibo.it [http://campus.unibo.it/]

Teaching methods

Lectures and seminars.

Assessment methods

The exam will consist in an oral tests aimed at assessing the student's understanding and knowledge of the topics set out during the course.

Teaching tools

PC, websites.

The file of the lessons are available at AMS Campus -AlmaDL - University of Bologna : http://campus.unibo.it [http://campus.unibo.it/]

Office hours

See the website of Andrea Tarozzi