07732 - Clinical Pathology (A-K)

Course Unit Page

Academic Year 2018/2019

Learning outcomes

To allow the students to acquire the fundamental notions for a critical evaluation and interpretation of the results of the main clinical laboratory tests. In particular, the student will learn to recognize and discuss the clinical meaning of laboratory data which characterize the following pathological conditions: acute and chronic inflammations; coagulation disorders; lipid disorders; hepatic disorders, renal disorders; diabetes; acid-base disorders.

Course contents

- Serum proteins. Serum protein electrophoresis (SPE); SPE patterns associated to specific diseases; acute phase reactants (APRs) and erythrocyte sedimentation rate (ESR).

- Laboratory test for the diagnosis of coagulation disorders. Laboratory tests for the evaluation of platelet function, coagulation cascade and fibrinolytic system; laboratory definition of the hypercoagulability disorders.

- Laboratory tests for the diagnosis of disseminated intravascular coagulation (DIC). Pathophysiology of DIC; laboratory definition of the phases of coagulation cascade activation, fibrinolytic system activation and coagulation factor consumption.

- Laboratory tests for the diagnosis of lipid disorders. Plasma lipoproteins and their metabolism; lipoproteins and atherosclerosis; quantitative and qualitative analysis of plasma lipoproteins.

- Laboratory tests for the diagnosis of diabetes. Classification of diabetes; metabolic effect of diabetes; laboratory tests for the diagnosis and for the follow-up of diabetic patients.

- Laboratory tests for the diagnosis of acid-base disorders. Respiratory and metabolic acidosis and alkalosis; blood gas analysis in the simple and complex disruptions of acid-base balance.

- Laboratory tests for the diagnosis of hepatic disorders. Bilirubin and urobilinogen; serum enzymes indicative of cytolysis and cholestasis; albumin/globulin ratio; coagulation factors.

- Laboratory tests for the diagnosis of renal system disorders. Urine analysis (physical, chemical and microscopic examination); urea, creatinine and uric acid; clearance tests; functional tests.

Readings/Bibliography

- Giorgio Federici: Medicina di Laboratorio. Terza edizione 2008, Mc Graw Hill libri Italia (Milano)

- Michael Laposata: Medicina di Laboratorio: la diagnosi di malattia nel laboratorio clinico. 2012, Piccin Nuova Libraria S.p.A. Padova.

- Italo Antonozzi e Elio Gulletta: Medicina di Laboratorio: Logica & Patologia Clinica. 2013, Piccin Nuova Libraria S.p.A. Padova.

 

Teaching methods

Frontal lessons for 16 hours (2 CFU).

Assessment methods

The final oral exam aims to assess whether the student has acquired the fundamental notions for a critical evaluation and interpretation of the results of the main clinical laboratory tests which characterize the following pathological conditions: acute and chronic inflammations; coagulation disorders; lipid disorders; hepatic disorders, renal disorders; diabetes; acid-base disorders.

Teaching tools

The slides shown during the lessons are available at the Web site: http://campus.unibo.it/ Username e password are reserved to students of Bologna University.

Office hours

See the website of Davide Trerè