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93821 - Research and Development of Recombinant and Biological Drugs

Academic Year 2026/2027

                
                        Docente:
                        Silvia Turroni
                    
                        Credits:
                        4
                    
                        SSD:
                        CHEM-07/C
                    
                        Language:
                        Italian
                    
                        Teaching Mode:
                        In-person learning (entirely or partially)
                        
                            Campus:
                            Bologna
                        
                            Corso:
                            Single cycle degree programme (LMCU) in
                            Pharmaceutical Chemistry and Technology (cod. 5986)

                                    Course Timetable
                                
from Oct 27, 2026 to Dec 04, 2026

Learning outcomes

By the end of the course, students will have acquired a basic understanding of molecular genetic approaches to the recombinant production of new drugs and protein engineering techniques to improve their pharmacokinetic characteristics.

Course contents

Use of microbial hosts (bacteria and yeasts) and mammalian cell lines for the production of recombinant drugs (protein hormones, fibrinolytics, coagulants, anticoagulants)

Industrial scale-up and downstream

Protein engineering approaches to improve the pharmacokinetics of recombinant drugs

Development of recombinant organisms for producing biological drugs (chimeric and humanized monoclonal antibodies, cytokines, immunotoxins)

Drug targeting using immunoproteins

Pharmacomicrobiomics

Readings/Bibliography

Slides and notes taken during the lessons are essential for exam preparation.

Teaching methods

Lectures with the support of explanatory slides.

Assessment methods

Theoretical knowledge will be verified by an oral test.

1. The exam will be administered in person, except in cases of local health or flooding conditions, in risk areas as per the new regulations, or if the student is vulnerable (an assessment will be carried out by the SLD service). Each case will be assessed individually and, if the requirements are met, the exam may be taken via the TEAMS platform.

2. Students with SLD or temporary or permanent disabilities are recommended to contact the relevant university office in good time (https://site.unibo.it/studenti-con-disabilita-e-dsa/en). The Office will be responsible for proposing any adaptations to the students concerned, but these must be submitted for the teacher's approval at least 15 days in advance. The teacher will then evaluate them in relation to the course's educational objectives.

3. The use of AI is prohibited. Any use constitutes a violation of academic integrity.

Teaching tools

PC, projector

Office hours

See the website of Silvia Turroni