90932 - Biomolecular Basis of Anatomical Pathology

Academic Year 2024/2025

  • Docente: Sofia Asioli
  • Credits: 6
  • SSD: MED/08
  • Language: English
  • Moduli: Sofia Asioli (Modulo 1) Antonio De Leo (Modulo 2) Antonio De Leo (Modulo 3)
  • Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2) Traditional lectures (Modulo 3)
  • Campus: Bologna
  • Corso: Second cycle degree programme (LM) in Medical Biotechnology (cod. 9081)

Learning outcomes

Discuss the principal epidemiologic, morphologic, phenotypic, clinicopathologic features, and etiopathogenesis of common neoplastic and non neoplastic disorders, focusing on cardiovascular and neuromuscolar disorders. Describe the methods used to process and analyze tissue samples for diagnostic Anatomic Pathology, including histopathology and ultrastructural laboratory instrumentation and devices. Discuss innovative technologies for early diagnosis of disease, and for the identification of new molecular targets for tumor therapies.

Course contents

 Definition of Anatomic Pathology

 Methods and Techniques in Anatomic Pathology

 Tumor classification

 Tumor of Central Nervous System and of pituitary: pathology and molecular diagnostics

 Neurodegenerative diseases: pathology and molecular diagnostics

 Neuromuscular diseases: muscle pathology

 Ultrastructural diagnostic (Electron microscopy)

 Ultrastructural markers in Tumor diagnosis

 Molecular diagnostic and prognostic markers in solid tumors

 Tumors of the respiratory system: pathology and molecular diagnostics

 Tumors of gastroenteropancreatic system: pathology nd molecular diagnostics

 Tumors of the female reproductive system: pathology and molecular diagnostics

 Tumors of the endocrine and neuro-endocrine system: pathology and molecular diagnostics

The course will include 1 CFU of practical activity (Laboratory) through viewing and discussion of slides and interpretation of molecular data.

Readings/Bibliography

Kumar, Cotran, Robbins "Basic Pathology", Saunders eds

World Health Classification of Central Nervous System Tumor 2021 5ed.

Teaching methods

Conventional lectures and student working group

Case study

Hybrid and Integrative Digital Teaching

Assessment methods

The student will be evaluated after oral examination about:

1. General principles of Anatomic Pathology and Molecular Diagnostics (Techniques and methodology)

2. Histopathological and molecular features of solid tumors

3. Discussion of cases

Teaching tools

Ex -cathedra teaching, conventional

Student working Group about main diagnostic issues

Case study and plenary discussion

Orario di ricevimento

Consulta il sito web di Sofia Asioli

Office hours

See the website of Sofia Asioli

See the website of Antonio De Leo

See the website of Antonio De Leo