67123 - Technology and Legislation of Herbal Products

Learning outcomes

After completing this course, the student has knowledge of keyctechniques that enable the preparation of herbal products or more generally of formulations of healthy interest. In particular has the necessaryknowledge related to the bioavailability and release from traditional and innovative vehicles.

In addition, the student has adequate knowledge of national and community legislation on medicinal plants and herbal products.

Course contents

Part I - Technology and Legislation of Herbal Products (Prof.ssa Barbara Luppi, 6 cfu)

Regolatory framework of products containing botanicals.

LADME system. Bioavalability and administration routes. Release of an active substance from a dosage form.

Strategies to enhance solubility. Complex, micelle and salt formation.

Solid dosage forms. Powders. Granulates. Tablets. Capsules. Coated dosage forms. Properties, formulation, preparative technologies and controls.

Liquid dosage forms. Solutions. Emulsions. Suspensions. Properties, formulation, preparative technologies and controls.

Semisolid dosage forms. Ointments, creams, gels and pastes. Properties, formulation, preparative technologies and controls.

Micro e nanoparticles. Micro/nanosphere. Micro/nanocapsules. Liposomes. Properties, formulation, preparative technologies and controls.

Part II - Formulation of Herbal Products (Prof.ssa Barbara Luppi, 3 cfu)

Preparation of different dosage forms containing botanicals.

Readings/Bibliography

F. Bettiol, F.F. Vincieri. Manuale delle Preparazioni Erboristiche. Tecniche Nuove, Milano, III Ed. 2021

P. Colombo et al., Principi e Tecnologie Farmaceutiche, Casa Editrice Ambrosiana, Milano, II Ed. 2015

P. Minghetti. Legislazione Farmaceutica, Casa Editice Ambrosiana, MIlano, X Ed. 2021

Slides discussed during the course.

Teaching methods

Lectures and practical laboratory.

As concerns the teaching methods of this course unit, all students (including all the international incoming exchange students, i.e. ERASMUS) must attend Module 1, 2 online [https://www.unibo.it/it/servizi-e-opportunita/salute-e-assistenza/salute-e-sicurezza/sicurezza-e-salute-nei-luoghi-di-studio-e-tirocinio], while Module 3 on health and safety is to be attended in class. Information about Module 3 attendance schedule is available on the website of your degree programme ("studiare"--"formazione obbligatoria su sicurezza e salute").

Assessment methods

Oral examination on the whole program (theoretical and practical modules). The exam will also include the discussion of the formulation aspects of a food supplement on the market. For the oral examination, registration by AlmaEsami list is required.

Teaching tools

Videoprojector and PC.

Office hours

See the website of Barbara Luppi