91043 - Pharmacology and Pharmacotherapy II

Learning outcomes

At the end of the course the student: - knows the main molecular mechanisms and the pharmacodynamic and therapeutic profile of drugs active on the central nervous system, on renal and cardiovascular functions, on respiratory and gastro-intestinal functions, on inflammation and on the immune system, on blood cells and on coagulation and aggregation of platelets, minerals and vitamins; - knows the drugs that influence endocrine functions; - is able to evaluate the efficacy and safety of drugs and their ability to prevent and treat certain diseases or alleviate their symptoms; - knows the main adverse and collateral effects that may limit their use; - is able to recognize the interactions between drugs; - apply the knowledge learned for the conduct of the profession, for the proper storage and dispensation of drugs, to inform and educate on the use of medicines; - possesses the knowledge that allows him to report adverse drug reactions; - apply the knowledge learned for the conduct of the profession, for the proper storage and dispensation of medicines, to inform and educate on the use of medicines and to monitor the management of the appropriateness in the use of medicines and the continuity of adherence to drug therapy in chronic therapies.

Course contents

CENTRAL NERVOUS SYSTEM PHARMACOLOGY

- Antipsychotic drugs

- Drugs for the treatment of anxiety and insomnia disorders

- Agents for the treatment of affective disorders

- Drugs effective in the therapy of the epilepsies

- Drugs effective in the therapy of neurodegenerative acute diseases (stroke), chronic diseases (Parkinson's disease and Alzheimer's disease) e rare diseases (Huntington's disease, Amyotrophic Lateral Sclerosis)

- Drug dependence and addiction

Treatment of pain

- Opioid analgesics and antagonists

- Non-opioid analgesics

PHARMACOLOGY OF THE CARDIOVASCULAR SYSTEM

- Drug therapy for atherosclerosis

- Antihypertensive agents

- Antihypotensive agents and shock

- Agents used in the treatment of heart failure

- Antiarrhythmic agents

- Drugs used for the treatment of angina pectoris

- Pharmacological treatment of vascular diseases

RENAL FUNCTION PHARMACOLOGY

- Diuretics and other drugs for edema

- Agents affecting the renal conservation of water

PHARMACOLOGY OF HEMATOPOIETIC SYSTEM

- Anti-anemic agents

- Antiplatelet agents

- Coagulant and anticoagulant agents

- Thrombolytic and antithrombolytic agents

PHARMACOLOGY OF RESPIRATORY SYSTEM

- Cough suppressants, expectorans, mucolytics

- Drugs used in treatment of asthma

PHARMACOLOGY OF GASTROINTESTINAL SYSTEM

- Agents used for control of gastric acidity and treatment of peptic ulcers

- Emetic and antiemetic agents

- Prokinetic agents

- Agents used for constipation

- Agents used for diarrhea and inflammatory bowel disease

- Agents used for biliary and pancreatic disease

DRUG THERAPY OF INFLAMMATION

- Nonsteroidal anti-inflammatory drugs (nsaids)

- Steroidal anti-inflammatory drugs

- Disease-modifying antirheumatic drugs (dmards)

- Drugs used in the treatment of gout

- Antihistamines

ENDROCRINE PHARMACOLOGY

- Oral hypoglycemic agents and the pharmacology of the endocrine pancreas

- Thyroid hormones and antithyroid drugs

- Adrenocorticotropic hormone; corticosteroids and their synthetic analogs; inibitors of the synthesis and actions of corticosteroids

- Reproductive hormone, estrogens and progestins, contraceptive drugs, androgens

- Hormones and agents affecting calcification and bone turnover

- Pharmacological therapy for obesity

Readings/Bibliography

Main Textbook

 

Basic and Clinical Pharmacology

Bertram G. Katzung, Todd W. Vanderah

15^th Edition - McGraw Hill

 

Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series)

Karen Whalen

7^th Edition - Wolters Kluwer

 

Textbook to be used for further information

 

Goodman & Gilman's: The Pharmacological Basis of Therapeutics

Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann

13^th edition - McGraw Hill

 

Stahl's Essential Psychopharmacology

Stephen M. Stahl

5^th Edition - Cambridge University Press

Teaching methods

Lectures

Assessment methods

The exam consists in a written test with thirty multiple choice questions and three open questions aimed at assessing the student's understanding and knowledge of the topics set out during the course.

The open questions will be selected from a known list of open questions that student will find in https://virtuale.unibo.it/ . The written test will be performed at https://eol.unibo.it/. The student will have 30 and 60 minutes to answer the multiple choice and open questions, respectively.

The final mark is the sum of the score obtained for each question. The student can get a score of 0.5 for each correct answer to multiple choice questions and a maximum score of 5 for each answer to open question.

Teaching tools

PC

Slides

Overhead projector

Students can find slides regarding the course material used by teacher during the lessons on Alma Campus.

Office hours

See the website of Andrea Tarozzi