90947 - Pediatrics

Learning outcomes

Screening of translocations with prognostic significance in pediatric acute leukemias. In vitro reproduction of translocations of pediatric oncohematological interest through editing with CRISPR / Cas9. Methods used: electroporation, extraction of nucleic acids, amplification of the fusions with PCR, running on agarose gel and analysis of the To achieve a basic knowledge of physiological and pathological processes regulating the growth and the development of children in particular in regard to the following aspects: - Ages of life - Development, growth and related disorders - Microbiota in pediatrics- Pediatric leukemia and biological background- Pediatric solid tumors and biological background - Genetic background of pediatric tumors and cancer predisposition - Chromosomal aberrations and pediatric syndromes- Vaccinations. To achieve a basic knowledge of: physiological and of the pathological processes of the following neonatal conditions: neonatal transition; hypoxic-ischemic encephalopathy; pulmonary diseases of term and preterm infants; necrotizing enterocolitis; intraventricular hemorrhage and periventricular leukomalacia; oxidative diseases of preterm infants; monitoring technologies in neonatal intensive care; neonatal microbiome.

Course contents

Pediatrics

- definition

- history

- age of life

-Hematological non-oncologic diseases of childhood

- Pediatric leukemia and biological backgroud

- Pediatric solid tumors and biological background

- Genetic background of pediatric tumors and cancer predisposition

- Chromosomal aberrations and pediatric syndromes

- Microbiota in pediatrics

- Vaccinations

Readings/Bibliography

Nelson Essentials of Pediatrics

Slides

Teaching methods

Classical teaching modalities with virtual reproduction of emblematic clinical cases with direct participation by students

Assessment methods

Oral examination

To pass the examination the student is requested to show a basic knowledge of physiological and pathological processes the development of children. To know in details the most common pathological conditions of infancy and to be well trained in discussing pediatric clinical cases. To summarize decision-making algorithms, provide a correct differential diagnosis, prognosis, and treatment choice of the most common pediatric diseases.

The end-of-course exam aims to assess the achievement of the following educational objectives:

- Knowledge of the basic principles of pediatrics in the aspects relating to history, age of life, prevention and communication to the pediatric patient.

- Knowledge of the biological background of the most important pediatric syndromes, tumors and developing diseases.

- Knowledge of the biological background of hematological conditions of childhood, vaccination and immunological development

The purpose of the oral exam is to verify the student's ability to apply his or her knowledge and to make the necessary logical-deductive connections. Gradation of the final grade: Preparation on a very limited number of topics covered in the course and analytical skills that emerge only with the help of the teacher, expressed in an overall correct language → 18-19; Preparation on a limited number of topics covered in the course and ability to autonomous analysis only on purely executive matters, expression in correct language → 20-24; Preparation on a large number of topics covered in the course, ability to make independent choices of critical analysis, mastery of specific terminology → 25-29; Basically exhaustive preparation on the topics covered in the course, ability to make autonomous choices of critical analysis and connection, full mastery of specific terminology and ability to argue and self-reflection → 30-30L.

Teaching tools

Slides and On-line simulations of clinical cases

Office hours

See the website of Riccardo Masetti

See the website of Silvia Martini