00148 - Organic Chemistry

Learning outcomes

The Organic Chemistry course aims to provide the basic principles of organic chemistry. We will describe natural and synthetic organic compounds, illustrating that the main synthetic methodologies and the mechanisms of formation (both in the laboratory and in natural systems), together with the structure-reactivity relationships and the supramolecular interactions. Particular attention will be paid to the chemistry of functional groups, to the stereochemistry and to carbocyclic and heterocyclic systems, as a useful introduction to the courses of pharmaceutical chemistry, biochemistry and pharmacology.

Course contents

Structure and Bonding

Acids and Bases

Introduction to Organic Molecules and Functional Groups

Alkanes and Cycloalkanes

Stereochemistry

Understanding Organic Reactions

Alkyl Halides -Nucleophilic Substitution and Elimination Reactions

Alcohols, Ethers, and Epoxides

Alkenes - electrophilic addition

Alkynes

Oxidation and Reduction

Radical Reactions

Conjugation, Resonance

Benzene and Aromatic Compounds - electrophilic aromatic substitution

Carboxylic Acids and the Acidity of the O–H Bond

Introduction to Carbonyl Chemistry; Organometallic Reagents

Aldehydes and Ketones—Nucleophilic Addition

Carboxylic Acids and Their Derivatives—Nucleophilic Acyl Substitution

Substitution Reactions of Carbonyl Compounds at the α Carbon

Carbonyl Condensation Reactions

Carbohydrates

Nucleic Acids

Amines, Alkaloids, Amino Acids and Proteins

Lipids

 

Readings/Bibliography

One of those handbooks:

1. Janice Gorzynski Smith – Fondamenti di Chimica Organica – McGraw-Hill
2. Brown & Foote – Chimica Organica – EdiSES
3. T. W. Graham Solomons, Craig B. Fryhle – Chimica Organic
4. John McMurry – Chimica Organica – Piccin

Teaching methods

The topics listed in the program will be fully covered, with a particular attention to the reaction mechanisms.

Assessment methods

The preparation is tested by a written exam, whose aim is to verify both the knowledge of the subject.

Teaching tools

Overhead projector, PC, blackboard

Office hours

See the website of Claudia Tomasini

See the website of Luca Valgimigli