Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea


INMARE stands for “Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea”. It is a collaborative Innovation Action to streamline the pathways of discovery and industrial applications of new marine enzymes and bioactives for targeted production of fine chemicals, drugs and in environmental clean-up applications. The INMARE consortium will unify the multidisciplinary expertise and facilities of academic and industry partners. This will include integrating the following core activities: advanced technologies to access and sample unique marine biodiversity hotspots; state-of-the art technologies for construction of metagenomic libraries; innovative enzyme screening assays and platforms; cutting-edge sequence annotation pipelines and bioinformatics resources; high-end activity screening technology; bioanalytical and bioprocess engineering facilities and expertise, nanoparticle-biocatalysts; high-quality protein crystallization and structural analysis facilities and experts in IP management for biotechnology. The companies involved in the project are market leaders in enzyme production and biocatalysis processes designed to efficiently deliver safer (pharmaceuticals) cheaper (agriculture) and biobased (biopolymers) products. They also have impressive track record in environmental clean-up technologies and are committed to promoting public understanding, awareness and dissemination of scientific research. The main emphasis will be focused on streamlining and shortening the pipelines for enzyme and ‘bioactive compound’ discovery towards industrial applications through the establishing of marine enzyme collections with a high proportion of enzymes-“allrounders”. The project will also prioritize the identification of novel lead products and the delivery of improved prototypes for new biocatalytic processes.

Project details

Unibo Team Leader: Giulio Zanaroli

Unibo involved Department/s:
Dipartimento di Ingegneria Civile, Chimica, Ambientale e dei Materiali

Bangor University(United Kingdom)

Other Participants:
Inofea Gmbh (Switzerland)
Seascape Consultants Ltd (United Kingdom)
The Governing Council Of The University Of Toronto (Canada)
evocatal GmbH (Germany)
Novozymes A/S (Denmark)
Jacobs University Bremen Ggmbh (Germany)
Università  degli Studi di MILANO (Italy)
Heinrich-Heine-Universität Düsseldorf (Germany)
Tuc Technical University Of Crete (Greece)
Vilniaus Universitetas (Lithuania)
Universitetet i Bergen - University of Bergen (Norway)
Consiglio Nazionale Delle Ricerche (Italy)
Pharma Mar S.A. (Spain)
Universitat Hamburg (Germany)
Cluster Industrielle Biotechnologie CLIB2021 e.V. (Germany)
University College Cork (Ireland)
ALMA MATER STUDIORUM - Università di Bologna (Italy)
Unifob As (Norway)
Bayer Technology Services Gmbh (Germany)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento Instituto Superior Técnico (Portugal)
Agencia Estatal Consejo Superior De Investigaciones Cientificas (Csic) (Spain)
Fachhocschule Nordwestschweiz (Switzerland)
The London School of Economics and Political Science (United Kingdom)

Total Eu Contribution: Euro (EUR) 5.999.557,13
Project Duration in months: 48
Start Date: 01/04/2015
End Date: 31/03/2019

Cordis webpage
Project website

Oceans This project contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.

UE flag This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 634486