PAIN-Net

Molecule-to-man pain network

Abstract

Neuropathic pain affects 5% of the general population and 40% of patients with neurological diseases, and has a key role in the pathophysiology of cancer pain that affects up to 50% of patients in the early disease stage and 30% of survivors, causing an enormous social burden. Treatments are inadequate with less than 50% of patients achieving 50% of pain relief at best, while up to 30% of cancer pain patients experience insufficient analgesia. Signatures of individual susceptibility to pain and analgesic responsiveness are urgently needed to improve patients’ management. Such advances are expected to originate from integrated clinical, basic science and entrepreneurial research readily translating scientific findings into benefits for patients. To consolidate these aims, a new generation of scientists with wide knowledge in neuropathic pain, focused research skills and experience in the interaction with biotechnology companies is needed. The PAIN-Net programme, based on a highly innovative platform of training-through-research and strongly committed to such objectives, will support such talented and inspired early stage researchers. Their research projects, embedded in an advanced molecule-to-man pain network, will contribute to better understanding individual susceptibility to pain and analgesics responsiveness based on next generation sequencing, whole exome sequencing, epigenetics and pharmacogenomics studies, nociceptor and sodium channel functioning based on biophysics and proteomics studies, targeted analgesics based on high-throughput screening, targeted analgesic delivery based on encapsulated cell bioreactor implants, and to the development and extensive characterisation of the first knock-in mouse models of sodium channel-related neuropathic pain based on the CRISP-Cas technology. Most of all, the PAIN-Net programme will offer the unique opportunity to enhance scientific capabilities and prepare to high level academic or private applied research career.

Project details

Unibo Team Leader: Paolo Garagnani

Unibo involved Department/s:
Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale

Coordinator:
Istituto Nazionale Neurologico Carlo Besta(Italy)

Other Participants:
NsGene A/S (Denmark)
Neuroscience Technologies Slp (Spain)
Maastricht University (Netherlands)
ALMA MATER STUDIORUM - Università di Bologna (Italy)
Yale University (United States of America)
Di.V.A.L. Toscana Srl (Italy)
Ospedale San Raffaele S.R.L. (Italy)
Centre Europeen De Recherche En Biologie Et Medecine (France)
Fondazione IRCCS Istituto Nazionale dei Tumori (Italy)

Third parties:
Crac Careers Research And Advisory Centre Ltd (United Kingdom)

Total Eu Contribution: Euro (EUR) 3.354.464,57
Project Duration in months: 48
Start Date: 01/02/2017
End Date: 31/01/2021

Cordis webpage

Good health and well-being This project contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.

UE flag This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 721841