Technology characterizing a specific genetic trait of patients affected by some tumoral pathologies

The invention, applied in the clinical field, has the function of characterizing a specific genetic trait of patients affected by some tumoral pathologies (such as colon or breast cancer), with the aim of improving the prognosis and the choice of an optimal therapy.

Title of the patent PCR primers for the characterization of the genetic trait “ODC1 +316 A/G SNP” in patients affected by cancer
Thematic area Biomedical
Ownership Alma Mater Studiorum – Università of Bologna
Inventors Giovanni Perini, Paolo Pigini
Protection Italy, with possibility to extend internationally
Licensing status Available for licensing agreements
Keywords ODC1; SNP; primer; allele-specific; genotyping
Filed on Jan 16, 2020

Some genetic traits can influence disease outcome. The mentioned genetic trait, known as "ODC1 +316 A / G SNP", has been associated with survival of patients with colon or breast cancer. Its characterization is therefore important to recognize the tumor aggressiveness and subsequently to choose an appropriate therapy.

The technology consists of DNA molecules specifically designed to be used in clinical analysis techniques (called PCR) for the characterization of the mentioned genetic trait in patients’ DNA samples.

This type of technology is commonly applied in clinical analysis laboratories. However, there is currently no product specifically designed for the mentioned genetic trait ("ODC1 +316 A / G SNP"), for which less efficient and more expensive technologies are the only available option. The clinical methodology would therefore benefit from a substantial improvement.