Pharmaceutical preparations for transdermal use

New pharmaceutical combination, characterized by facility to penetrate and speed of absorption, which can be used for the treatment of muscular pain and acute backache

Title of the patent Pharmaceutical preparations for transdermal use
Thematic area Pharmaceutical
Ownership Alma Mater Studiorum - Università di Bologna
Inventors Cavallari Cristina, Barbara Luppi, Anna Maria Di Pietra, Lorenzo Rodriguez
Protection Europe
Licensing status Available for licensing agreement
Keywords Anti-inflammatory, analgesic, emulgel, topic administration
Filed on Apr 26, 2006

The development of topical formulations of non-steroid anti-inflammatory drug (NSAID) was due to the side effects that may be caused by orally ingested NSAIDs. In particular, NSAIDs can cause stomach upset. And, with long term use, the side effects may become more serious – heart attacks, kidney failure and gastrointestinal bleeding. Topical drugs have been associated with fewer of these side effects. Although the topical drug application does not present all the disadvantages of the oral and parenteral administrations, drugs are rarely administrated by skin. Thus, there is still a remarkable necessity to render available new formulations for skin use that allow to overcome some disadvantages deriving from skin absorption (facility to penetrate and speed of absorption).

The invention concerns a new pharmaceutical combination which can be used for the  treatment of muscular pain and acute backache. It consists of a topical vehicle containing a combination of a non-steroid anti-inflammatory drug (NSAID) and a commonly used therapeutical substance that can act synergically in order to achieve a relatively high level of efficacy. From a technological point of view, this formulation is an emulgel, i.e. an oil-in-water emulsion in which the external phase is jellified.

The invention concerns a new pharmaceutical combination which can be used for the  treatment of muscular pain and acute backache. It consists of a topical vehicle containing a combination of a non-steroid anti-inflammatory drug (NSAID) and a commonly used therapeutical substance that can act synergically in order to achieve a relatively high level of efficacy. From a technological point of view, this formulation is an emulgel, i.e. an oil-in-water emulsion in which the external phase is jellified. This presence promotes the skin absorption and can have some advantages:

  • Improved application properties with respect to the traditional formulations like creams and ointments;
  • More rapid and complete transfer of the active ingredient from the vehicle to the skin and consequent greater efficacy;
  • The product is easy to spread, favouring application on large areas of skin;
  • The product is not greasy and does not leave traces after application;
  • Excellent skin-feel;
  • Easier penetration of the drugs through the skin due to the presence of absorption promoters;

In vitro and in vivo tests have demonstrated that the active ingredients are quickly absorbed.