35801 - General Veterinary Pathology and Molecular Oncogenesis

Learning outcomes

Acquisition of knowledge on the etiology and the pathogenetic mechanism of the main basic lesions.

Course contents

Veterinary general pathology (3 CFU - Giuseppe Sarli)

Etiology, pathogenesis and morphology of atophy, necrosis, apoptosis and gangrene. Inflammation: changes in vascular flow and caliber, exudation and leukocyte extravasation, fluid and cellular components of inflammation, molecular basis of inflammation, acute and chronic inflammations. Anaemia: classification and pathogenesis. Hypoxia: classification and pathogenesis. Physiopatology of the body temperature (passive hyperthermia, fever). Radiation pathology.

Molecular oncology (2 CFU - Brunetti Barbara)

Biology of tumor growth: benign and malignant neoplasms (differentiation, anaplasia, rates of growth, cancer stem cells and cancer cell lineages, local invasion, metastasis). Molecular basis of cancer (essential alterations for malignant transformation, the normal cell cycle, self-sufficiency in growth signals, oncogenes, protooncogenes, oncoprotein, insensitivity to growth inhibitory signals, tumor suppressor genes, evasion of apoptosis, DNA repair defect and genomic instability in cancer cells, telomerase, development of sustained angiogenesis, invasion  and metastasis, stromal microenvironment and carcinogenesis, dysregulation of cancer-associated genes). Molecular basis of multistep carcinogenesis. Carcinogenic agents and their cellular interaction (chemical carcinogenesis, radiation carcinogenesis, microbial carcinogenesis). Host defense against tumors, tumor immunity (tumor antigens, antitumor effector mechanisms, immune surveillance). Clinical characteristic of tumors. Effect of the tumour in the host. Tumoral grading and staging. Laboratory diagnosis of tumours

Readings/Bibliography

• Marcato P.S., Anatomia e istologia patologica generale veterinaria, 1997 (Esculapio, Bologna).
• Robbins e Cotran Le basi patologiche delle malattie. Kumar V, Abbas AK, Fausto N. 7° ed, elsevier, 2006.
• Files available at Alm@ DL

Teaching methods

General pahology: 24  hours of lessons given as theoretical teaching.

Molecular oncology: 14,5 hours given as theoretical teaching and 1,5 as pratical work.

Assessment methods

For the final exam are provided at least 3 questions.

Registration to the exam by the AlmaEsami list.

Teaching tools

Projector connected to a light microscope and PC.

Office hours

See the website of Giuseppe Sarli

See the website of Barbara Brunetti