- Docente: Valentina Giorgio
- Credits: 10
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 5904)
-
from Mar 08, 2024 to Apr 15, 2024
Learning outcomes
At the end of the course the student will be aware of the basis of Metabolic Biochemistry in human tissues and diseases.
Course contents
Metabolic biochemistry
Glucose metabolism
Citric acid cycle (TCA or Krebs cycle): reactions, energetic yield, regulation. Amphibolic role of the cycle. Glycogen metabolism: glycogenesis, glycogenolysis and regulation. Gluconeogenesis: primary glucogenic precursors, reactions, and storage. Coordinated regulation of glycogen synthesis and degradation. Coordinated regulation of glycolysis and gluconeogenesis. Pentose phosphate pathway.
Bioenergetics
Mitochondrial structure and the internal membrane: oxidative phosphorylation. Electron flow through the respiratory chain: formation of electro chemical potential, proton gradient usage; 1) ATP synthase and chemiosmotic mechanism of ATP synthesis. Respiratory control. Inhibitors and uncouplers. 2) Ca2+ and metabolite transport through the internal membrane. 3) NAD+/NADPH transhydrogenase. 4) Thermogenesis. Electron dispersion and radical oxygen species.
Nitrogen metabolism
Description of kinetics, control, and regulation of nitrogen metabolism. Amino acid oxidations and urea production.
- Metabolic fate of amine groups
- Nitrogen excretion and urea cycle
- Amino acid degradation
- Biosynthesis of amino acids, nucleotides, and related molecules.
- Nitrogen metabolism
- Amino acid biosynthesis
- Amino acid derivatives
- Nucleotide biosynthesis and degradation
Readings/Bibliography
The text books will be indicated during lessons.
Teaching methods
Frontal lessons.
Assessment methods
Oral exam.
Teaching tools
Supplemental material is provided during lessons.
Office hours
See the website of Valentina Giorgio