- Docente: Katia Scotlandi
- Credits: 2
- Language: English
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Medical Biotechnology (cod. 9081)
Learning outcomes
Precision Medicine directly relates data, knowledge and skills that pertain the areas of genetic data of the patient, appropriate experimental models and functional/pharmacological analysis in order to correctly contextualize knowledge for the development of tailored treatments. At the end of the course, students will become familiar with concepts and techniques related to pharmacological resistance; development of representative experimental models; development antibodies; targeted and cell therapy.
Course contents
Precision Medicine: fundamentals and sources. Excursion among: Gene Therapy; Targeted therapies, DNA editing; mutational medicine.
Fundamentals of "omics" technologies and examples of their application in different types of diseases.
Next-generation sequencing in diagnosis: how to choose the right analytics solutions to meeting different challenges
Targeted therapies in oncology: fundamentals and sources; advantages and limits
Targeted therapies in oncology: antibodies versus tyrosine kinase inhibitors. Advantages and limits
How to exploit targeted therapy concepts in immunotherapy. Combination treatments.
Drug resistance
Using next-generation sequencing to advance precisione medicine
From mutational medicine to personalized medicine: the importance of representative experimental models
Functional genomics
work group on clinical applications of precision medicine
Readings/Bibliography
Original research articles provided by the lecturer as .pdf files.
Pdf files of lectures
Teaching methods
The course will be structured as follows
-frontal lectures with PowerPoint slides
-discussion of original research articles on topics related to the lectures
Assessment methods
Student learning will be checked at the end of the course by an oral exam.
The final mark will be calculated as the weighted mean (based on CFUs) of the marks obtained in all the courses of FRONTIERS IN MEDICAL RESEARCH (I.C.)
Teaching tools
Teaching slides and materials will be available on line at Unibo e-learning website https://virtuale.unibo.it [https://virtuale.unibo.it/] upon registration with Unibo institutional credentials.
Office hours
See the website of Katia Scotlandi