57359 - Analysis of Medicines I (GR-B)

Learning outcomes

At the end of the course, which also provides laboratory exercises in a single place, the student acquires the knowledge and practice for the recognition and verification of purity of compounds of pharmaceutical interest, in inorganic structure, by means of specific chemical assays and analytical techniques. And 'able to apply the acquired knowledge to the use of the methods reported in the Italian Official Pharmacopoeia and European Pharmacopoeia.

Course contents

ANALYSIS OF MEDICINES I
80 hours- theoretical lessons 32
Laboratory lessons 48
Introduction to pharmaceutical analysis. Qualitative methods of analysis.
Measurement methods and preliminary operations in chemical analysis. Italian Pharmacopoeia (FU) and European Pharmacopoeia.
Ions of pharmaceutical and toxicological interest: properties, identification reactions, pharmacological and toxicological activity (ammonium salts, silver, lead, mercury, arsenic, antimony, copper, bismuth, iron, aluminium, zinc, manganese, cobalt,  calcium, barium, magnesium, sodium, potassium, lithium, sulphates, nitrates, phosphates, borates, chlorides, bromides, iodides, carbonates, acetates).
Amphoterism. Complex ions; structure of complex ions. Stability and importance of complex ions in analysis. Chelates. Oxidation-reduction reactions.
The colloidal state.
Introduction to spectroscopic analysis: flame atomic emission spectroscopy.
Limit tests of impurities of inorganic compounds of FU.
Introduction to chromatographic methods: ion-exchange chromatography. Laboratory lessons: identification reaction of ions, limit tests of impurities. Identification and tests of inorganic compounds of FU. Separation of ions by ion-exchange chromatography.

Readings/Bibliography

A. Araneo.  Chimica Analitica Qualitativa

P. Barbetti M. G. Quaglia.  L'Analisi qualitativa in chimica farmaceutica e tossicologica inorganica

Teaching methods

32 hours of theoretical lessons held by the professor from October  to January, and 48 hours of individual practical work, supervised by the same professor, distributed among 16 consecutive afternoons.

Assessment methods

The examination at the end of the course aims to assess the achievement of learning objectives:
- Know and know how to apply in practice the characteristic reactions of cations and anions identification of individual components of inorganic drugs;
- Know and know how to apply in practice the characteristic reactions (limit tests) to assess the purity of inorganic raw materials, following the methods reported in the Italian Official Pharmacopoeia and European Pharmacopoeia;
- Knowledge of action and toxicity of inorganic compounds of pharmaceutical interest;
- Know and apply in practice  ion-exchange chromatography; - Demonstrate ability to learn the material that they can integrate the knowledge gained in the course with those of previous years and to be able to deal with the courses of the following years.
The assessment of learning is implemented through practical test laboratory, carried out at the end of the exercises in a single place, and oral examination. The test practice, unlimited validity, is preliminary oral examination.
Students to whom the Board of Study Course validates the signature frequency acquired in previous career, they must pass the test laboratory practice before the oral exam.
The final grade for the course Analysis of Medicines I is defined by the oral test on three specific questions on topics related to the main objectives of the course.

 Note: To access the teaching (lectures and exercises) must have passed the examination of General and Inorganic Chemistry

 

Teaching tools

Teacher's written lesson notes, Italian and European Pharmacopoeia.

Lesson slides: available at http://campus.unibo.it/

Laboratory handouts: available at the copy shops in Via S. Donato or on-line

Office hours

See the website of Laura Garuti