- Docente: Sabrina Angelini
- Credits: 6
- SSD: BIO/14
- Language: English
- Moduli: Sabrina Angelini (Modulo 1) Patrizia Romualdi (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Bologna
- Corso: First cycle degree programme (L) in Genomics (cod. 9211)
Learning outcomes
By the end of the course, the student understands how to correlate gene expression or single-nucleotide polymorphisms with pharmacokinetics and pharmacodynamics, as well as drug receptor target effects, in order to explore the influence of acquired and inherited genetic variation on drug response in patients.
Course contents
Modulo 1. Introduction to pharmacogenetics and pharmacogenomics: general consideration; Pharmacogenomics and individualized therapy: promises, opportunities and limitations; human genome: DNA variation, repeat elements and their role in medicine; human genome and markers of drug response; Ethnicicty and phamacogenomics; Association studies in pharmacogenomics (metabolyzing enzymes, transportes, plasma binding protein, drug targets); genomics application facilitating the understanding of drug efficacy and toxicity; Role of pharmacogenomics in drug discovery and therapeutics; Pharmacogenomics of chemotherapeutic agents in cancer treatment.
Modulo 2. Introduction to pharmacoepigenomics: general aspects; -Interactions between genome and environment in the modulation of the pharmacological response; -Interactions between genome and environment in the modulation of side effects.
Pharmacoepigenomics deals with: - the influence that epigenetic alterations (DNA methylation, histone modifications, chromatin remodeling, non-coding RNA dysregulation) exert on drug efficacy and safety; -the influence of the effects that drugs may have on the epigenetic machinery; -Genes involved in pharmacogenomics are also affected by epigenetic modifications conditioning the therapeutic outcome; -Drugs may modify epigenetic functions under normal and pathological conditions.
- Epigenetic drugs with potential effects in CNS disorders; How epigenetic phenomena affect drug response in CNS diseases: addiction, chronic pain, neurodegenerative diseases, neuropsychiatric diseases. -Epigenetic drugs: DNA methyltransferase inhibitors, histone deacetylase inhibitors, histone acetyltransferase modulators, histone methyltransferase inhibitors, histone demethylase inhibitors, non-coding RNAs (miRNAs). -Ubiquitin proteasome system and interacions with epigenetic modifications. -Animal models of human diseases.
Readings/Bibliography
Scientific literature (mostly from PubMed)
Teaching methods
Lectures and seminars.
Assessment methods
The exam will consist in two oral tests aimed at assessing the student's understanding and knowledge of the topics set out during the course.
The examination of the modules 1 and 2 consists of an interview; the two modules can be given separately.
The marks obtained for each module, in proportion to the number of credits, contribute to the final grade of thirty.
Teaching tools
PC, websites.
Office hours
See the website of Sabrina Angelini
See the website of Patrizia Romualdi