- Docente: Emidio Capriotti
- Credits: 4
- SSD: BIO/10
- Language: English
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Bioinformatics (cod. 8020)
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from Oct 17, 2022 to Oct 28, 2022
Learning outcomes
At the end of the course, the student acquires the basic elements of biomolecular structure and function and the most appropriate models for their descriptions. In particular, the student acquires skills concerning: - Basic elements of cell biology; - Basic elements of structural and functional biology; - Basic notions of kinetics and thermodynamics for modelling relevant biological functions in Systems Biology.
Course contents
- Thermodynamics Principles, State Variables and Spontaneous Processes.
- Transition Phase, Mixtures, Osmosis. Equilibrium Constant and Chemical Potential.
- Reaction Kinetics, Activation Energy, Enzymes and Michaelis-Menten Mechanism
- Proteins, Amino Acid Properties, Electronegativity and Chemical Bonds
- Protein Structure, Stabilizing interactions, Hydrophobic Effect and Protein-Protein Interactions
- Experimental techniques for structural determination: X-ray and NMR.
- Biological Systems: Signal transduction, Rhodopsin, Protein Sequence and Structure Comparison and Functional Genomics.
Readings/Bibliography
Suggested readings, and material online.
- Biophysics: An Introduction (2° Edition). by Roland Glaser, Springer.
- Biophysical Chemistry by James P. Allen, Wiley.
- Molecular and Cellular Biophysics by Meyer B. Jackson, Cambridge University Press.
Teaching methods
Lectures and exercises.
Assessment methods
The assessment based on a project report and an oral exam. The aim is to evaluate the student's understanding of the learning outcomes of the course, focusing on the major aspects of the biological complexity.
Teaching tools
Online
Office hours
See the website of Emidio Capriotti