Course Unit Page
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Teacher Fulvia Farabegoli
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Credits 6
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SSD MED/04
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Teaching Mode Traditional lectures
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Language Italian
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Campus of Bologna
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Degree Programme First cycle degree programme (L) in Biological Sciences (cod. 8012)
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Course Timetable from Mar 02, 2022 to May 04, 2022
SDGs
This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.
Academic Year 2021/2022
Learning outcomes
Students will have an understanding of pathology and general causes of diseases: genetic diseases, cell and tissue injury (chemical, physical and biological causes, mechanisms and consequences), the body reaction to injury (acute and chronic inflammation, regeneration and healing), physiology of the Immune system (innate and acquired immunity, antibodies, B and T lymphocytes), oncology (genetic and cell mechanisms underlying spontaneous and experimental neoplasm development), cardiovascular pathology.
Course contents
Introduction to pathology and general causes of diseases.
Genetic disorders. The cellular basis of diseases: adaptations
(hyperplasia, hypertrophy, atrophy, metaplasia). Reversible and
irreversible cell injury (necrosis and apoptosis). Mechanisms of
cell injury. Intracellular accumulation. Acute inflammation:
general features, vascular changes, cellular events and molecules
involved. Chemical mediators of inflammations. Systemic effects of
inflammation. Tissue repair (regeneration, healing and fibrosis).
Aspecific and specific chronic inflammation. Granulomas. Edema and
shock. Infectious diseases (virus and bacteria and toxins).
Esotoxins and endotoxins. Enviromental pathology: physical and
chemical causes of injury (ionizing and ultraviolet radiations),
(drugs, industrial and nutritional agents). Neoplasia:
classification, benign and malignant neoplasms, epidemiology,
molecular basis of cancer, multistep carcinogenesis, biology of
cancer cell, metastasis. Fundaments of cardiovascular pathology
(hypertension, thrombosis, embolism and atherosclerosis).
Immunology: the Immune System. Structure and Components. Innate Immunity (defence mechanisms, fagocitosis, Natural Killer, complement and cytochins). The Adaptative Immune System: general chracteristics. Antigen capture and presentation: the Major Histocompatibility Complex I and II. T lymphocytes and the T Cell Receptor. B Lymphocytes and the antigen receptor. The Immunoglobulines and the antibodies diversity. The humoral immune response. The cell mediate immunity. Antigene-antibody reactions: use in biology and medicine. The elimination of microbes and toxins by humoral immunity.Tolerance.
Readings/Bibliography
Patologia: Robbins and Cotran, Le basi patologiche delle malattie
(Patologia generale 1° volume) Ed. Elsevier OR M. Parola,
Patologia generale, EdiSES. Very concise: E. Rubin, H.M. Reisner – “Patologia generale – l’essenziale” - Piccin Editore
Immunologia: Abbas e Lichtman, Le basi dell'Immunologia.
Fisiopatologia del sistema Immunitario, Ed. Elsevier
Teaching methods
5CFU as taught class. 1 CFU will deal withanalysis of histopathology slides (on line available too): hydropic and fatty change, coagulative and colliquative necrosis, acute inflammation, tissue repair and scar formation, chronic inflammation (TBC and foreign body granuloma),atherosclerosis, neoplasms (benign and malignant neoplasm).
Assessment methods
Oral test
Teaching tools
Slides: avalaible on line, by username and password, on Virtuale Insegnamenti on line
Office hours
See the website of Fulvia Farabegoli
Alumni