08956 - Clinical Biochemistry

Course Unit Page

Academic Year 2021/2022

Learning outcomes

The student, at the end of the module, thanks to the knowledge of the fundamental principles of chemistry and organic molecules of biological interest, is able to evaluate the biological and biochemical parameters in biological and in vivo samples, also in relation to pathophysiological states, at different levels of structural organization, from single molecules to cells, tissues, organs, up to the whole organism.

Course contents

  • Introduction to the course.
  • Clinical biochemistry in vivo and ex vivo in the field of laboratory medicine.
  • The role of laboratory medicine in the clinical context.
  • Elements of organization of a biomedical laboratory.
  • Reference values and decision-making levels.
  • Performance of a diagnostic test: sensitivity, specificity, predictive value.
  • The pre-analytical, analytical and post-analytical phases of laboratory investigations.
  • Biological, pre-analytical and analytical variability.
  • Clinical indications, contraindications, side effects and complications.
  • Types of laboratory tests: routine, urgency, emergency.
  • Screening test.
  • From patient to laboratory test: patient preparation, sample collection, handling and storage
  • Examples of the role of the nurse in the classification of muscle disorders, in laboratory diagnostics of cerebrospinal fluid, in in vivo molecular diagnostics.



  • Teaching material in pdf
  • M. Ciaccio e G. Lippi, Biochimica Clinica e Medicina di Laboratorio, EDISES

Teaching methods

Frontal lessons with Power Point presentations

Assessment methods

The level of learning will be verified at the end of the course through a computer-based test with multiple choice questions, aimed at ascertaining the student's knowledge of all the topics of the integrated course.

The test consists of 31 questions. Each question has 4 answers, of which only one is correct. Each correct answer is worth one point.
Whoever reaches a minimum of 18 points passes the test. The number of correct answers, if greater than or equal to 18, corresponds to the final grade. With 31 correct answers you have praise.

Due to the COVID-19 health emergency, the final exam could take place remotely on the Microsoft Teams or ZOOM platform. Specific indications will be provided after registering for the exam in Almaesami.

Teaching tools

Didactic material in Power Point presentations.

Office hours

See the website of Stefania Evangelisti