75216 - General Pathology

Course Unit Page

Academic Year 2018/2019

Learning outcomes

At the end of the course, students will be able to understand the causes and pathogenic mechanisms of human diseases. Occupational and environmental causes of disease will be examined as well as their pathological consequences.

Course contents

Cellular pathology: health and disease concepts, etiology and pathogenesis; cellular adaptations, reversible and irreversible cell injury: necrosis and apoptosis.

Inflammatory-reparative response: etiology and classification of acute inflammation, chemical mediators, vascular changes and exudate formation, cellular events and phagocytosis, systemic consequences and etiopathogenesis of fever; chronic and granulomatous inflammation; adult stem cells, reparative response: tissue repair and wound healing, fibrosis. Hemosthasis and coagulation cascade. Atherosclerosis.

Immunology and immunopathology: cells and tissues of the immune system; innate and specific immunity; antigen processing and presentation; humoral and cell-mediated immune responses; antibody; complement; tolerance. Hypersensitivity. Autoimmunity. Immunodeficiency syndrome. Vaccines.

Oncology: the neoplastic cell; tumor classification; carcinogenesis; epidemiology and prevention; molecular genetics of cancer, oncogenes and tumor suppressor genes; tumor progression; metastasis.

Hereditary diseases: genetic diseases: autosomal dominant and recessive disorders, X-linked disorders, chromosomal disorders.

Environmental and nutritional diseases: diseased caused by chemical or physical agents; nutritional disorders.


  1. E. Rubin, H.M. Reisner – “Patologia generale – l’essenziale” - Piccin Editore (recommended)
  2. G.M. Pontieri - “Patologia generale e fisiopatologia generale. Per i corsi di laurea in professioni sanitarie” III edizione - Piccin Editore (reference book)
  3. J.A.M. Maier – “Patologia generale e fisiopatologia per le professioni sanitarie” II edizione – Mc Graw Hill Editore (reference book)

Teaching methods

Lectures (24 hours).

Assessment methods

Student learning will be checked at the end of the course through a an oral/written exam.

Teaching tools

Teaching slides will be available on line (AMS Campus).

Links to further information


Office hours

See the website of Manuela Ferracin