84923 - Pharmacology and Pharmacotherapy II

Learning outcomes

At the end of the course the student: - knows the main molecular mechanisms and the pharmacodynamic and therapeutic profile of drugs active on the central nervous system, on renal and cardiovascular functions, on respiratory and gastro-intestinal functions, on inflammation and the immune system, on blood cells and on the coagulation and aggregation of platelets, minerals and vitamins; - knows the drugs that influence endocrine functions; - is able to evaluate the effectiveness and safety of drugs and their ability to prevent and treat certain diseases or alleviate their symptoms; - knows the main adverse and side effects that can limit its use; - is able to recognize interactions between drugs; - applies the knowledge learned to carry out the profession, for the correct storage and dispensing of medicines, to inform and educate on the use of medicines; - has the knowledge that allows him to report adverse reactions to drugs; - applies the knowledge learned to carry out the profession, for the correct storage and dispensing of medicines, to inform and educate on the use of medicines and monitor the management of the appropriateness in the use of medicines and the continuity of adherence to pharmacological therapy in chronic therapies.

Course contents

MODULE I - Teacher: Prof. Andrea Bedini

GASTROINTESTINAL PHARMACOLOGY: Pharmacotherapy of gastric acidity, peptic ulcers and GERD. Antiemetics and prokinetic drugs. Antidiarrheal and laxative drugs.

ANAESTHESIA, ANALGESIA, ADDICTION: General anaesthetics. Opioid agonists and antagonists. Substances of abuse.

CARDIOVASCULAR PHARMACOLOGY AND PHARMACOTHERAPY: Treatment of heart failure and ischemic heart disease. Antiarrhythmics. The renin-angiotensin system. Treatment of hypertension. Diuretics.

PHARMACOLOGY OF BLOOD FUNCTIONS: Hematopoietic agents.  Treatment of anemia and blood disorders. Hypolipidemic drugs.

PULMONARY PHARMACOLOGY AND PHARMACOTHERAPY: Pharmacotherapy of asthma and COPD. Antitussive and mucolytic drugs.

HORMONS, HORMON ANTAGONISTS, ENDOCRINE PHARMACOLOGY: Hypothalmic and pituitary hormons. Estrogens, progestins, androgens and related antagonists. Endocrine pancreas and pharmacotherapy of diabetes. Hypoglycemic drugs. Modulation of feeding and energetic metabolism. Agents affecting mineral ion homeostasis and bone turnover. Thyroid and anti-thyroid drugs.

 

MODULE II - Teacher: Prof. Monica Baiula 

NEUROPHARMACOLOGY AND PSYCHIATRIC DISORDERS: Pharmacotherapy of epilepsies. Treatment of CNS degenerative disorders. Pharmacotherapy of psychosis and mania. Treatment of depression and anxiety disorders. Hypnotics and sedatives. Pharmacotherapy of multiple sclerosis.

INFLAMMATION PHARMACOLOGY: Introduction to immune system and inflammation. Hystamin, bradykinin and their antagonists. Lipid-derived autacoids: eicosanoids and PAF. NSAIDs. Glucocorticoids. Pharmacotherapy of gout. Immunosuppressants and tolerogens. Pharmacotherapy of rheumatoid arthritis.

PHARMACOLOGY OF HEMOSTASIS: Anticoagulants. Thrombolytics. Antiplatelet drugs. Fibrinolytics and antifibrinolytics.

OCULAR PHARMACOLOGY: Pharmacotherapy of glaucoma. Pharmacotherapy of AMD and diabetes-induced macular edema. 

 

 

Readings/Bibliography

Stefano Govoni, Santi Mario Spampinato, Pierluigi Navarra et al. Farmacologia seconda edizione. Casa Editrice Ambrosiana, 2024.

Testo da utilizzare per approfondimenti

Goodman & Gilman. Le basi farmacologiche della terapia. Con espansione online

Autori: Laurence L. Brunton, Randa Hilal-Dandan, Bjorn C. Knollmann

Casa editrice Zanichelli - Edizione 2019

Teaching methods

Slides are available on Virtuale.

Assessment methods

The exam consists of two parts:

-first, a 120 min long written exam made of 10 open questions on all the topics included in the course program;

-second, an oral exam for those students who passed the written exam.

Students are required to enroll for exams via AlmaEsami.

Teaching tools

Slides are displayed during classes and are available on Virtuale.

Office hours

See the website of Andrea Bedini

See the website of Monica Baiula