23276 - General Pathology and Immunology

Learning outcomes

At the end of the course, students will be able to understand the causes and pathogenic mechanisms of human diseases, and the etiology of structures, functions, and control mechanisms alterations at several levels of integration. The students will learn the principles and biological basis of immune response regulation, including the pathophysiology of immune response impairment in major diseases.

Course contents

Module 1

MECHANISMS OF DISEASES

Cell injury and adaptation. Cell death. Stem cells

ENVIRONMENTAL AND NUTRITIONAL DISEASES Diseased caused by chemical or physical agents; nutritional disorders and obesity.

ONCOLOGY

The neoplastic cell; tumor classification; carcinogenesis; epidemiology and prevention; molecular genetics of cancer, oncogenes and tumor suppressor genes; tumor progression; metastasis.

HEREDITARY DISEASES

Genetic diseases: autosomal dominant and recessive disorders, X-linked disorders, chromosomal disorders. Familial tumors. Multifactorial disorders (Alzheimer’s disease).

 

Module 2

Cellular pathology: the damage, DAMPS; PAMPS, MAMPS;

Inflammatory-reparative response: etiology and classification of acute inflammation, chemical mediators, vascular changes and exudate formation, cellular events and phagocytosis, systemic consequences and etiopathogenesis of fever; chronic and granulomatous inflammation, pathogenesis of tuberculosis; adult stem cells, reparative response: tissue repair and wound healing, fibrosis.

Immunology: cells and tissues of the immune system; innate and specific immunity; antigens; major histocompatibility complex; antigen processing and presentation; humoral and cell-mediated immune responses; antibody; complement; tolerance.

Immunopathology: Hypersensitivity Autoimmunity. Immunodeficiency syndrome. Graft rejection.

General physiopathology: hemostasis and hemorrhagic diseases; risk factors of atherosclerosis, formation of atheromatous plaque and related consequences; thrombosis; embolism. Diabetes.

Readings/Bibliography

Teaching slides are recommended. Teaching material is available online on virtuale.unibo.it website, upon registration to the Course.

REFERENCE BOOK LIST

Le basi della patologia generale di Sunil R. Lakhani. Ed. Zanichelli (recommended)

J.A.M. Maier – “Patologia generale e fisiopatologia per le professioni sanitarie” II edizione – Mc Graw Hill Editore

Patologia Generale e Fisiopatologia Generale

F. MAINIERO et al. 2018/2019. Ed. Piccin

Teaching methods

Lectures (36 hours).

Assessment methods

Student learning will be checked at the end of the course through a written test. The overall knowledge will be assessed using a written exam structured as multiple-choice questions. The exam will be held in presence using personal computers.

The exam is composed by 33 questions. Each valid answer grants 1 point. The student needs to reach 18 points to pass the exam. The number of correct answers corresponds to the final mark, if the number is greater or equal to 31 the mark will be 30 cum laude.

Students are required to know their Institutional credentials to sustain the exam.

Students with specific requirements are invited to contact professor Manuela Ferracin in advance.

Teaching tools

Teaching slides will be available on line at Unibo e-learning website https://virtuale.unibo.it

Links to further information

https://corsi.unibo.it/laurea/Infermieristica/sezione-formativa-bologna-2

Office hours

See the website of Manuela Ferracin

See the website of Chiara Pirazzini