- Docente: Katia Scotlandi
- Credits: 2
- Language: English
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Medical Biotechnology (cod. 9081)
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from Oct 09, 2023 to Nov 20, 2023
Learning outcomes
Precision Medicine directly relates data, knowledge and skills that pertain the areas of genetic data of the patient, appropriate experimental models and functional/pharmacological analysis in order to correctly contextualize knowledge for the development of tailored treatments. At the end of the course, students will become familiar with concepts and techniques related to pharmacological resistance; development of representative experimental models; development antibodies; targeted and cell therapy.
Course contents
Precision medicine: Fundamental concepts and sources. Excursion between: Gene Therapy; Targeted therapies, DNA editing; mutational medicine.
Molecular diagnostics: how to choose the right analysis solutions to address the different challenges
Targeted therapies in oncology: foundations and sources; advantages and limitations
Targeted therapies in oncology: antibodies against tyrosine kinase inhibitors. Advantages and limitations
Targeted therapies in oncology: Targeted protien degradation
How to exploit the concepts of targeted therapy in immunotherapy. Combined treatments.
Drug resistance
Pharmacogenetics and pharmacogenomics
Using next-generation sequencing to advance precision medicine
From mutational medicine to personalized medicine: the importance of representative experimental models for functional genomics
Readings/Bibliography
Original research articles provided by the lecturer as .pdf files.
Pdf files of lectures
Teaching methods
The course will be structured as follows
-frontal lectures with PowerPoint slides
-discussion of original research articles on topics related to the lectures
Assessment methods
Student learning will be checked at the end of the course by an oral exam.
The final mark will be calculated as the weighted mean (based on CFUs) of the marks obtained in all the courses of FRONTIERS IN MEDICAL RESEARCH (I.C.)
Teaching tools
Teaching slides and materials will be available on line at Unibo e-learning website https://virtuale.unibo.it [https://virtuale.unibo.it/] upon registration with Unibo institutional credentials.
Office hours
See the website of Katia Scotlandi