02404 - Haematology (A-K)

Learning outcomes

Upon completion of the course, the student possesses the knowledge to recognize and interpret the major diseases of the blood and hemolymphopoietic system, both neoplastic and non-neoplastic. In particular, the student is able to:-interpret the signs, symptoms and laboratory data characterizing anemias; acute, myeloid and lymphoid leukemias; chronic myeloproliferative syndromes; lympho-imuno-proliferative syndromes; plateletopenias and coagulation diseases;-know the main methods of application of autologous and allogeneic stem cell transplantation.

Course contents

Integrated course in Hematology, Clinical Immunology and Rheumatology
HEMATOLOGY: didactic program (exam program).
Hemolymphopoiesis: hierarchical organization. Stem cells. Bone marrow microenvironment and growth factors.
Erythropoiesis and erythropoietin.
Anemias. Pathogenetic classification. Diagnosis, clinical symptoms and signs, main laboratory tests, blood count.
Anemias from reduced erythroblastogenesis.
Anemias from reduced erythrocytogenesis. Ineffective erythropoiesis. Vitamin B12 and folic acid/folate metabolism. Megaloblastic anemias: clinical and laboratory pictures, hints of therapy.
Anemias from impaired hemoglobin synthesis. Thalassemias, with special reference to beta-thalassemias: clinical and laboratory pictures, hints of therapy. Beta-thalassemias minor. Cooley's disease. Generalities on alpha-thalassemias and hemoglobinopathies (sickle cell anemia).
Iron metabolism. Siderocarence and sideropenic anemia: clinical and laboratory pictures, hints of therapy.
Physiologic and pathologic hemolysis: causes, clinical and laboratory pictures. Spherocytosis. Paroxysmal nocturnal hemoglobinuria. Hemolytic anemias from enzyme deficiencies. Immune hemolytic anemias.

Leukemias: etiopathogenetic causes and molecular basis. Acute and chronic leukemias.
Acute myeloid leukemias: cytological features, genetic-molecular alterations, clinical and laboratory pictures, hints of therapy.
Acute lymphoid leukemias: cytologic and immunophenotypic features, genetic-molecular alterations, clinical and laboratory pictures, hints of therapy.
Myelodysplastic syndromes.
Chronic myeloproliferative syndromes (Chronic myeloid leukemia. Polycythemia vera. Essential thrombocythemia. Myelofibrosis with splenic-hepatic myeloid metaplasia): genetic-molecular alterations, clinical and laboratory pictures, hints on therapy.
Chronic lymphoproliferative syndromes, with special reference to Chronic Lymphatic Leukemia: immunophenotypic features, clinical and laboratory pictures, hints of therapy. Generalities on prolymphocytic leukemia and hair cell leukemia.
Monoclonal gammopathies. Monoclonal Gammapathy of undetermined significance (MGUS) and Multiple Myeloma: genetic-molecular alterations, clinical and laboratory pictures, hints of therapy. Generalities on Waldenstrom's macroglobulinemia.
Nodal and extranodal lymphomas: WHO classification.
Hodgkin's lymphoma: epidemiology and etiopathogenesis, clinical pictures, hints of therapy.

Non-Hodgkin's lymphomas, nodal and extranodal, high-grade and low-grade aggressive: clinical and laboratory pictures, hints of therapy.
Megakaryocytopenia. Plateletopenias: pathogenetic classification, diagnosis, clinical signs and symptoms, main laboratory tests, hints of therapy. Immune thrombocytopenic purpura (Werlhof's disease).
Congenital coagulopathies: hemophilia A and B, von Willebrand disease.
Acquired coagulopathies: From defects in liver synthesis, Disseminated intravascular coagulation.
Allogeneic and autologous stem cell transplantation: general principles and clinical applications.

 

Readings/Bibliography

S. Tura, Corso di Malattie del sangue e degli organi emopoietici, Società editrice ESCULAPIO, ultima edizione.

Harrison, Principles of Internal Medicine (capitoli relativi)

Teaching methods

2-hour face-to-face and/or platform teams lectures

Assessment methods

La verifica dell’apprendimento avviene attraverso lo svolgimento di una prova scritta finalizzata a valutare il raggiungimento degli obiettivi didattici del corso. L’esame è svolto congiuntamente dai Docenti delle tre discipline che compongono il corso.

la prova sarà composta da 60 domande a risposte multiple (4 o 5), delle quali solo una sarà quella corretta. Il tempo concesso per lo svolgimento dell’elaborato sarà di 60 minuti.

Le domande saranno 20 per ciascun modulo componente il corso integrato.

Alle risposte corrette sarà corrisposto un determinato punteggio, mentre le risposte sbagliate o le domande senza alcuna risposta non avranno alcun punteggio.

Teaching tools

pubblicazione delle diapositive delle lezioni su IOL

Office hours

See the website of Michele Cavo