00358 - Histology

Learning outcomes

Describe the structure and functional organization of tissues at a cellular and subcellular level.

Course contents

At the end of the course the student will have acquired basic informations required to understand the morpho-functional bases of the organization of the different organs of the human body. It will illustrate how the cell structures are modified in the process of differentiation to generate cells specific for each tissue and how these modifications guide the physiological functions of the tissues. More specifically, the student will acquire the knowledge necessary to perform microscopic observations and on the general organization of the different organs of the human body.

PROGRAM

Histological differentiation and organization into four basic tissues.

Epithelial tissues

Ultrastructure and function of epithelial cells. Histological classification.

Covering epithelium. Structure functions, classification and distribution. Junction complexes, adhesion molecule relationships and cytoskeletal elements. Keratinization mechanisms. Regeneration.

Glandular epithelium. Structure and function of glands. Exocrine and endocrine secretion (parenchyma and stroma). Histology and function of Exocrine Glands. Classification. Overview of Endocrine System. Regulatory mechanism of endocrine secretion. Hormones.

Connective Tissue

Embryonic development and distribution. Cells and extracellular matrix (ECM): collagen and elastic fibers, amorphous ground substance. Role of different cellular elements. Classification.

Connective tissue proper. Classification. Mucous connective tissue. Loose connective tissue. Reticular and elastic tissues. Dense regular and irregular tissues. Adipose tissues (unilocular and multilocular).

Cartilage. Histological structure and classification. Perichondrium. Cartilage growth and repairing.

Bone. Trabecular and compact bone: cells and ECM. Direct and indirect ossification. Bone turnover.

Blood. Hematopoiesis. Structure and function of blood. Plasma and cells. Histology of bone marrow and emopoietic cell differentiation.

Muscle tissue

Classification and organization. Smooth muscle: ultrastructure and function. Contraction mechanism.

Skeletal Muscle: ultrastructure and organization of skeletal muscle fibers. Histology and function of Cardiac muscle.

Nervous tissue

Structural and functional organization of the nervous tissue. Types of neurons. Ultrastructure of myelinated and unmyelinated nerve fibers. Ultrastructure of synapses. Structure and function of glia.

Readings/Bibliography

- " Istologia umana per le professioni sanitarie " - AA VV- Ed. Idelson-Gnocchi

- "ISTOLOGIA per i corsi di laurea in professioni sanitarie" - Adamo, Comoglio, Molinaro et al. - Ed. PICCIN

- Adamo, Carinici et al. "Istologia" di V.Monesi , Piccin

- Junqueira, Carneiro. "Compendio di istologia. Testo ed atlante." Ed. Piccin

- Adamo, et al. Elementi di Istologia, Piccin

- Guida illustrata all'istologia di C. Rizzoli, M.A. Brunelli, C. Castaldini; Piccin Editore

- Istologia atlante di G. Bani, D. Bani, T. Bani Sacchi; Idelson-Gnocchi Editore

- Atlante di Istologia di Gianpaolo Papaccio; Idelson-Gnocchi Editore

- Dongmei Cui Atlante di Istologia con correlazioni funzionali e cliniche a cura di A. Filippini, A. Musarò, E. Ziparo; Piccin Editore

- Istologia. Testo e atlante con elementi di Biologia Cellulare e Molecolare. M.H. Ross, W. Pawlina, Casa Editrice Ambroiana

Teaching methods

Frontal lessons and open discussion.

Mandatory attendance 60% of lessons.

Assessment methods

The students will be evaluated by written exam, with multiple choice tests.

Teaching tools

Power-Point presentations

https://virtuale.unibo.it/

 

UNIBO-digital microscopy

https://unibo.smartzoom.com/s1241/course1328

https://virtuale.unibo.it/

Office hours

See the website of Enea Ferlizza