94495 - Applied Organic Chemistry: from the Laboratory to the Market

Learning outcomes

The target of the course is to give a general view of the critical aspects of Pharmaceutical Process Development starting from specific case histories. 

Particular attention will be dedicated to costs (design strategy and yield), sustainability (environmental impact), drug safety (impurities control). The students will have a good understanding of the challenges and knowledge necessary to produce drugs with increasing architectural complexity in a a global society and high regulated market. 

Course contents

1. Drug Discovery e Molecular Complexity.

2. Synthetic methodologies trends in the Pharma Industry. 

3. Intellectual Property.

4. Solid State.

5. Analytical Challanges in drug development. Genotoxic impurities, elemental impurities, nitrosamines etc. 

6. Green Technologies: catalysis  & flow chemistry.

7. Case histories of several drugs development form bench to market.

Readings/Bibliography

“From Bench to Market. The Evolution of Chemical Synthesis from Discovery to Industrial Production.”; Oxford University Press: Oxford, 2000.

Specific publications will be given to the students. 

Teaching methods

Frontal course with slides projected in class and commented with the help of interactive screens or blackboard.

Assessment methods

Oral Examination

Teaching tools

Copies of the slides in pdf will be provided to the students.

It is useful to remind that students cannot share or publish the slides of the course in full or in part.   

Office hours

See the website of Walter Cabri