- Docente: Patrizia Brigidi
- Credits: 3
- SSD: CHIM/11
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
-
Corso:
Single cycle degree programme (LMCU) in
Chemistry and Pharmaceutical Technologies (cod. 8412)
Also valid for Single cycle degree programme (LMCU) in Chemistry and Pharmaceutical Technologies (cod. 8412)
Learning outcomes
Aim of the course is the use of microorganisms in the industrial fermentative production of pharmaceutical compounds
Course contents
Use of recombinant bacteria and yeasts for the production of hormones, fibrinolytic agents, cytokines and recombinant toxins. Industrial processes and downstream. Development of recombinant organisms for the production of biologicals, such as chimeric and humanized monoclonal antibodies. Protein engineering to improve the pharmacokinetics of recombinant proteins. Targeting of drugs by immune-proteins.
Readings/Bibliography
Papers and reviews suggested by the teacher
Teaching methods
Lessons will address the development and employment of genetically modified organisms in the pharmaceutical industrial sector.
Assessment methods
The assessment of learning
takes place through final oral examination, which tends to ensure the acquisition of
knowledge on topics related to
the main learning
objectives of the course:
- Industrial use
of microorganisms for the production of primary
and secondary metabolites of pharmaceutical interest;
- Use of recombinant microorganisms for
the industrial production of heterologous
proteins of pharmaceutical
interest;
- Approaches
of protein
engineering to modify drug-kinetic characteristics of recombinant
proteins;
- Development
of biologics.
Teaching tools
PC, projector
Office hours
See the website of Patrizia Brigidi
SDGs
This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.