27868 - Laboratory of Organic Synthesis and Characterization (A-L)

Learning outcomes

Objective of the course is to develop basic skills in the synthesis of organic compounds by modern synthetic methods. The student will be able to analyze and purify substances by liquid chromatography. The student will develop basic skills in the identification of simple organic compounds through combined NMR, MS, IR

Course contents

Grade and safety information of organic reagents, solvents and commercial details. Reactions involving air and moisture sensitive reagents, Schlenk line and syringe techniques. Purification procedure of organic compounds by column chromatography. Acquire practice and techniques in organic synthesis by multistep synthesis.

Introduction to mass spettrometry for simple organic compounds, electron impact and electronspray spectra.  Nuclear Magnetic Resonance: chemical shifts in H-1 and C-13 NMR for the main class of organic compounds. Spin systems and Pople notation, Karplus equation in H-1 NMR. Interpretation of spectroscopic data for the identification of simple organic compounds by NMR, IR and MS combined spectra

Readings/Bibliography

Lecture Notes.

Electronic presentations on Insegnamenti online

Recommended Books:

Silverstein, Webster, Kiemle, Spectrometric Identification of Organic Compounds. Wiley

Mayo, Pike, Forbes, Microscale organic laboratory, Wiley

Leonard, Lygo, Procter, Advanced practical organic chemistry, Thorner Ed.

Keese, Braendel, Toube, Practical organic synthesis, Wiley

J.W.Lehman, Operational Organic Chemistry , Prentice Hall

Teaching methods

Oral lectures (3 CFU, 24 h) supported by multimedia techniques. Laboratory sessions (2 CFU, 32 h)to improve experimental skills in organic synthesis and characterization. Training in the interpretation of laboratory data and in writing laboratory report will be arranged (1 CFU, 12h).

Assessment methods

To pass the exam a candidate must have a positive evaluation in three parts: laboratory reports, written test on the identification of a simple organic compound by combined H-1, C-13 NMR, IR, MS spectra, and a viva voce.

Excellent degree (28-30) will be acquired with a good assessment  obtained with a very good knowledge of the course contents , a good usage of technical language, and high performance in reasoning and application of the competences.

Fairly good assessments (24-27) could be obtained with a good knowledge of the contents, an appropriate usage of technical language, but with a rote-learning.

Limited abilities in reasoning and application of the contents, a limited technical language, but a sufficient knowledge of contents will give a sufficient assessment (18-23)

Inadequate knowledge of contents and/or technical language and/or insufficiency in preliminary knowledge of pre-requirements will give a negative assessment.

Teaching tools

Oral lectures  were supported by multimedia techniques could be retrived on the web platform IOL upon registration.
Take notes during the lectures is mandatory.

Laboratory sessions  to improve experimental skills will be in the organic synthesis laboratory of the department "G.Ciamician".

Office hours

See the website of Daria Giacomini