11961 - Special Methodologies in Pharmaceutical Analysis (GR.B)

Learning outcomes

At the end of the course, which includes laboratory activities, the student: - possesses knowledge about the application of conventional and instrumental titrimetry reported as pharmacopoeial official methods; - possesses the core issues for the correct choice and application of analytical methods in pharmaceutical analysis.

Course contents

Non-aqueous titrations.

Potentiometry.

Conductimetry.

Voltammetry and polarography.

Ultraviolet and visible spectrophotometry.

Fluorometry.

Extraction techniques.

Chromatographic techniques

Readings/Bibliography

HARRIS , Chimica Analitica Quantitativa, Zanichelli, 2005

CAVRINI, ANDRISANO, Principi di Analisi Farmaceutica, Esculapio, 2013

HAGE, CARR, Chimica Analitica e Analisi Quantitativa,Piccin, 2012.

Teaching methods

The theoretical lessons are intended to provide the basic knowledge of instrumental techniques used in pharmaceutical analysis. During the laboratory activity the students will apply analytical procedures for identification and quantitation of active ingredients in pharmaceuticals.

Assessment methods

The assessment of learning will evaluate the achievement of the educational objectives of teaching, namely:
- The ability to apply the acquired theoretical and practical knowledge related to the determination of the purity of active ingredients and to the quality control of commercial formulations;
- The ability to critically understand and apply the analytical methods, including instrumental analytical methods, reported in the Italian Official Pharmacopoeia and European Pharmacopoeia.
The exam will be performed at the end of the laboratory activity and consists in a practical test on the achieved laboratory practice; in addition the final oral examination will be performed. The practical test has unlimited validity; the students should positively perform the practical lab test before the oral exam.

Teaching tools

The theoretical lessons will be held by using slides.

The lab activity will be carried out in laboratories equipped with specific reagents and analytical instrumentation (potentiometer, conductimeter, UV spectrophotometer, HPLC apparatus, etc.), suitable for the drug quality control.

Office hours

See the website of Alessandra Locatelli