00768 - General Pathology

Learning outcomes

This course will focus on the molecular basis of human diseases and the application of new technologies to the study of genetic disorders and cancer. The Students will acquire the appropriate knowledge of  some animal models for cancer analysis.

 

Course contents

Module 1

Cytogenetic methodology. Chromosome banding and morphology. Chromosome abnormalities. Chromosomal changes in neoplasia. Molecular cytogenetics, FISH, SKY and multiFISH. Application of CGH and arrayCGH.
Cancer genetics. Dominant transforming genes and tumor suppressor genes. Familial cancer syndromes. Genetic predisposition for common cancers (breast, colon, thyroid). DNA testing for cancer syndromes. Biochemical and molecular genetics of human diseases. Genomic imprinting.

Module 2

Molecular biology of cancer. Animal models for cancer analysis: principles and techniques. Lecture syllabus is available at: http://campus.unibo.it/290898/

 

Teaching methods

Lectures and seminars (24 hours Module I and 24 hours Module II).

Assessment methods

At the end of the course, the student will:

- acquire a cellular and molecular vision of the malignant transformation;
- know the main animal models for cancer analysis;
- know the applications of modern technologies to cytogenetics and molecular diagnostics.

For Module 1, the final test will consist in an oral exam aimed at verifying the students' knowledge on the course topics.

For Module 2, the final test will consist in a written exam composed of an open question on cancer biology (15 points) and a graphic exercise on animal models (15 points).

Teaching tools

Lectures will be supplied on informatic supports (http://campus.unibo.it/).

Office hours

See the website of Annalisa Pession

See the website of Daniela Grifoni