13880 - Pharmacology and Pharmacotherapy

Learning outcomes

Learning outcomes will be the most important knowledge of natural, sinthetic and biotechnologic drugs both at experimental (pharmacokinetic, pharmacodynamic, adverse effects) and at clinical level. To this aim the student will know the drug doses and the most important therapeutic strategies, including the drug associations, and the therapeutic contraindications; the student will be able to evaluate the risk/benefit and cost/benefit ratios of a drug therapy.

Course contents

Course I -  Pharmacology and Pharmacotherapy I - Prof. Andrea Tarozzi (40 ore)

Course II - Pharmacology and Pharmacotherapy II – Prof. Andrea Tarozzi (64 ore)

Course III - Chemotherapy- Prof. Andrea Tarozzi (24 ore)

CHEMIOTERAPY

-     Introduction

 

Microbial diseases

-     Antimicrobial agents: penicillins, cephalosporins and other b-lactam compounds; macrolides, ketolides and lincosamides; aminoglycosides; fluoroquinolones; glycopeptides; amphenicols; tetracyclines; rifamycins; sulfonamides e pyrimidines; drugs for tuberculosis.

-     Antifungal agents

-     Antiviral agents

 

Parasitic infections

-     Antiprotozoal agents: malaria; leishmaniasis; amebiasis, giardiasis and trichomoniasis; toxoplasmosis; trypanosomiasis.

-     Anthelmintic agents

-     Ectoparasiticides

 

Neoplastic disorders

-     Alkylating agents

-     Antimetabolites agents

-     Topoisomerase inhibitors

-     Microtubule inhibitors

-     Hormone antagonists

-     Other signal transduction inhibitors and cytotoxic antibodies

 

NERVOUS SYSTEM PHARMACOLOGY

Drugs acting at synaptic and neuroeffector junctional sites

-     Cholinergic agonists

-     Anticholinesterase agents

-     Antimuscarinic agents

-     Adrenergic receptor agonists and antagonists

 

Drug acting on the central nervous system

-     Antipsychotic drugs

-     Drugs for the treatment of anxiety and insomnia disorders

-     Agents for the treatment of affective disorders

-     Drugs effective in the therapy of the epilepsies

-     Drugs effective in the therapy of neurodegenerative acute diseases (stroke), chronic diseases (Parkinson's disease and Alzheimer's disease) e rare diseases (Huntington's disease, Amyotrophic Lateral Sclerosis)

-     Drug dependence and addiction

 

Treatment of pain

-     Opioid analgesics and antagonists

-     Non-opioid analgesics

 

General (brief mentioning) and local anesthetics

Drugs for treatment of primary headache

 

PHARMACOLOGY OF THE CARDIOVASCULAR SYSTEM

-     Drug therapy for atherosclerosis

-     Antihypertensive agents

-     Antihypotensive agents and shock

-     Agents used in the treatment of heart failure

-     Antiarrhythmic agents

-     Drugs used for the treatment of angina pectoris

-     Pharmacological treatment of vascular diseases

 

RENAL FUNCTION PHARMACOLOGY

-        Diuretics and other drugs for edema

-        Agents affecting the renal conservation of water

 

PHARMACOLOGY OF HEMATOPOIETIC SYSTEM

-     Anti-anaemic agents

-     Antiplatelet agents

-     Coagulant and anticoagulant agents

-     Thrombolytic and antithrombolytic agents

 

PHARMACOLOGY OF RESPIRATORY SYSTEM

-        Cough suppressants, expectorans, mucolytics

-        Drugs used in treatment of asthma

 

PHARMACOLOGY OF GASTROINTESTINAL SYSTEM

-        Agents used for control of gastric acidity and treatment of peptic ulcers

-        Emetic and antiemetic agents

-        Prokinetic agents

-        Agents used for constipation

-        Agents used for diarrhea and inflammatory bowel disease

-        Agents used for biliary and pancreatic disease

 

DRUG THERAPY OF INFLAMMATION

-        Nonsteroidal anti-inflammatory drugs (nsaids)

-        Steroidal anti-inflammatory drugs

-        Disease-modifying antirheumatic drugs (dmards)

-        Drugs used in the treatment of gout

-        Antihistamines

 

ENDROCRINE PHARMACOLOGY

-        Oral hypoglycemic agents and the pharmacology of the endocrine pancreas

-        Thyroid hormones and antithyroid drugs

-        Adrenocorticotropic hormone; corticosteroids and their synthetic analogs; inibitors of the synthesis and actions of corticosteroids

-        Reproductive hormone, estrogens and progestins, contraceptive drugs, androgens

-        Hormones and agents affecting calcification and bone turnover

-        Pharmacological therapy for obesity

Readings/Bibliography

1. ROSSI F., V. CUOMO, C. RICCARDI (a cura di) "Farmacologia. Principi di base e applicazioni terapeutiche", II ed., Torino, Edizioni Minerva Medica, 2011.

2a. KATZUNG B.G. "Farmacologia Generale e Clinica", VIII ed. it. a cura di Preziosi P., Padova, Piccin Editore, 2011.

2b. KATZUNG B.G. "Basic and clinical pharmacology", 11th ed., McGraw Hill Lange, USA, 2009.

3. GOLAN D.E., TASHJIAN A.H. Jr. “Principi di Farmacologia. Le basi fisiopatologiche della terapia”, ed. it. a cura di Biggio G., Monti E., Parolaro D., Perletti G., Milano, Casa Editrice Ambrosiana, 2006.

Teaching methods

Lectures

Assessment methods

Final examination is oral. Will be required to treat four subjects regarding:

1. Chemiotherapy (3 CFU) (if the result of the test of chemotherapy is positive, this question can be excluded )

2. Nervous system pahrmacology (3 CFU)

3. Pharmacology of the cardiovascular and hematopoietic system, and of renal function (4 CFU)

4. Pharmacology of the respiratory and gastrointestinal system; drug therapy on inflammation and endocrine system pharmacology (3 CFU) and Pharmacovigilance (3 CFU)

Teaching tools

PC

Slides

Overhead projector

Students can find slides regarding the course material used by teacher during the lessons on Alma Campus.

Office hours

See the website of Andrea Tarozzi