- Docente: Luigi Barbieri
- Credits: 3
- SSD: MED/04
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Rimini
- Corso: First cycle degree programme (L) in Nursing (cod. 8475)
Learning outcomes
The student, at the end of the teaching course, will be able to understand the causes and the pathogenetic mechanisms of human diseases, and the etio-pathogenesis of the main alterations in structure and function of the body, including regulatory and compensatory mechanisms. The student will comprehend the principles and functions of the immune system and the correlated immuno-pathology
Course contents
The program and the examination topics have been defined during the last lesson of the course
The program is indicative. The definitive program and the examination topics will bee defined during the last lesson of the course
Concepts of normality and gendre medicine
Homeostasis
Protein turnover
Body fluids
Plasma and serum
Functional reservoir, insufficiency, compense, scompense
Concept of biological damage
Concept of death
Congenital disease, teratogenesisAdaptations
Precaution principle
Biological effects of low temperatures
Biological effects of UV radiations
Biological effects of electric and magnetic fields
Chemical compounds: toxicity
Prions
Nutritional alterations
Adaptation mechanisms at cell, tissue and organ levels
Adaptation mechanisms: iperplasia, ipertrofia, ipo-/aplasia, ipo-/atrofia fisiologiche e patoogiche
Inducible enzymes
Dysplasia and metaplasia
Cellular death: necrosis and apoptosis
Tissue mass equilibrium
DNA damage and apoptosis
Alteration in apoptosis and in its regulation
Biological effects of free radicals
Role of calcium
Intra-cellular deposits
Acute inflammation: vascular events
Tattoos
Pneumoconioses: pulmonary mechanisms of particle cleaning and correlated pathologies
Asbesto's pathologies
Phagocytosis: generalities
Extra-cellular deposits
Protein misfolding
Inflammation: biological role
Acute inflammation: vascular events
Acute inflammation: cellular events
Acute inflammation: classification
Acute inflammations: chemical mediators
Arachidonic acid metabolites
Inflammation: systemic effects
The complement system
Phagocytosis: mechanisms and professional phagocytes
Concepts of immunity, antigen, antibody, natural and acquired immunity, active and passive immunity
Cell role in adaptive immunity
The humoral immune response: the response to extra-cellulare antigens
The cell-mediated immune response: response to intra-cellular antigens
Organ and system immunity
Histocompatibility antigens: functions and disease association
Functional anatomy of the immune system
Main aspects of the immune response: specificity, antigen diversity
Antibodies
Hypersensitivity: the four types
Autoimmunity: the thyroid paradigm
Neuropsicoendcrinoimmunology
Chronic inflammation: main aspects, ulcer pathogenesis, granulomas
Tissue repair and angiogenesis
Staminal cells
Senescence
General mechanism of edema formation
Readings/Bibliography
Free text:
Luigi Barbieri, Enrico Strocchi, Lezioni di Patologia generale, edizione digitale, Rimini, Polo Scientifico Didattico di Rimini, 2011. ISBN 9788897617006 published in http://amsacta.cib.unibo.it/3067/
Reference textbooks
Longo, D.L., Kasper, D.L., Jameson, J.L., Fauci, A.S. (2011) Harrison's principles of internal medicine. XVIII ed. Mc Graw Hill, New York
Kumar, V., Fausto, N, Abbas, A.K., Aster, J. (2009) Robbins and Cotran Pathologic basis of disease. VIII ed. Elsevier Saunders, Philadelphia
Kumar, V., Abbas, A.K., Aster, J. (2012) Robbins basic pathology. IX ed. Elsevier Saunders, Philadelphia
Lakhani, S.R., Dilly, S.A., Finlayson, C.J. (2009) Basic pathology. An introduction to the mechanisms of disease. IV ed. Arnold, London
Rubin, R., Stryer, D.S. (2008) Rubin's Pathology: clinicopathological foundations of medicine. V ed. Lippincott Williams & Wilkins, Philadelphia
Stevens, A., Lowe, J., Scott, I. (2009) Core Pathology. III ed. Elsevier Saunders, Philadelphia
Teaching methods
Frontal lessons and occasional internet content
Assessment methods
Written compositions on objects that have been concordated with the students (see the program) . Part of the exam may be through multiple choice test. The evaluation will be all inclusive of integrated course. The exam may be taken only as a whole. At the time of registering, complementary interrogation may be proposed
Teaching tools
Normal teaching devices
Links to further information
http://amsacta.cib.unibo.it/3067/
Office hours
See the website of Luigi Barbieri