- Docente: Claudia Tomasini
- Credits: 6
- SSD: CHIM/06
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Second cycle degree programme (LS) in Advanced Chemical Methodologies (cod. 0449)
Learning outcomes
This course wants to furnish some information on the chemical
synthesis, biosynthesis and characterization of the most important
classes of natural substances.
Some details on the structural determination and the total
synthesis of some famous natural product, such as quinine,
daunomycin and taxol will also be furnished.
Course contents
The following compounds will be described:
1) pheromones: structure and synthesis;
2) prostaglandins: classification, synthesis and
biosynthesis;
3) terpenes: classification and biogenesis;
4) sterols and corticoid and sexual hormones: structure, biogenesis
and chemical synthesis;
5) aromatic polyketides: biogenesis of phenols (low molecular
weight) and anthraquinones (high molecular weight);
6) shikimic acid derivatives and flavonoids;
7) alkaloids: classification and biogenesis;
8) antibiotics: penicillins, tetracyclines, streptomycins and
macrolides.
Le structural determinations and some famous syntheses of
daunomycin, taxol and quinine will also be described.
Readings/Bibliography
Paul M. Dewick - Chimica, Biosintesi e Bioattività delle Sostanze
Naturali - Piccin
John McMurry, Tadhg Begley - Chimica Bio-organica -
Zanichelli
K. C. Nicolaou, E. J. Sorensen - Classics in Total Synthesis -
VCH
Teaching methods
Frontal lessons.
All the topics listed in the program will be covered with
particular regard to a comparison between synthetic and
biosynthetic pathways that lead to natural compounds.
The students are encourage to produce short papers on selected
topics.
Assessment methods
The preparation is tested by an oral exam, whose aim is to verify the knowledge of the theoretical lessons.
Teaching tools
Overhead projector, PC, video projector
Office hours
See the website of Claudia Tomasini